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ISL1-based LIM complexes control Slit2 transcription in developing cranial motor neurons
LIM-homeodomain (HD) transcription factors form a multimeric complex and assign neuronal subtype identities, as demonstrated by the hexameric ISL1-LHX3 complex which gives rise to somatic motor (SM) neurons. However, the ...
Contralateral migration of oculomotor neurons is regulated by Slit/Robo signaling
Oculomotor neurons develop initially like typical motor neurons, projecting axons out of the ventral midbrain to their ipsilateral targets, the extraocular muscles. However, in all vertebrates, after the oculomotor nerve ...