Now showing items 1-3 of 3

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    Blocking Apoptotic Signaling Rescues Axon Guidance in Netrin Mutants 

    Newquist, Gunnar; Drennan, J. Michelle; Lamanuzzi, Matthew; Walker, Kirsti; Clemens, James C.; Kidd, Thomas (3/28/2013)
    Summary Netrins are guidance cues that form gradients to guide growing axons. We uncover a mechanism for axon guidance by demonstrating that axons can accurately navigate in the absence of a Netrin gradient if apoptotic ...
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    The Role of Apoptotic Signaling in Axon Guidance 

    Kellermeyer, Riley; Heydman, Leah M.; Mastick, Grant S.; Kidd, Thomas (2018)
    Navigating growth cones are exposed to multiple signals simultaneously and have to integrate competing cues into a coherent navigational response. Integration of guidance cues is traditionally thought to occur at the level ...
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    The WAGR syndrome gene PRRG4 is a functional homologue of the commissureless axon guidance gene 

    Justice, Elizabeth D.; Barnum, Sarah J.; Kidd, Thomas (2017)
    WAGR syndrome is characterized by Wilm's tumor, aniridia, genitourinary abnormalities and intellectual disabilities. WAGR is caused by a chromosomal deletion that includes the PAX6, WT1 and PRRG4 genes. PRRG4 is proposed ...