Author | Wu Y | |
Author | Yoder A | |
Author | Yu D | |
Author | Wang W | |
Author | Liu J | |
Author | Barrett T | |
Author | Wheeler D | |
Author | Schlauch, Karen A | |
Date Accessioned | 12/22/2015 | |
Date Accessioned | 2015-12-24T02:33:30Z | |
Date Available | 12/22/2015 | |
Date Available | 2015-12-24T02:33:30Z | |
Date of Issue | 10/17/2008 | |
Identifier (Citation) | Retrovirology. 2008 Oct 17;5:95. doi: 10.1186/1742-4690-5-95. | |
Identifier (URI) | https://www.ncbi.nlm.nih.gov/pubmed/18928553 | |
Description | Cofilin is an actin-depolymerizing factor that regulates actin dynamics critical for T cell migration
and T cell activation. In unstimulated resting CD4 T cells, cofilin exists largely as a phosphorylated
inactive form. Previously, we demonstrated that during HIV-1 infection of resting CD4 T cells, the
viral envelope-CXCR4 signaling activates cofilin to overcome the static cortical actin restriction. In
this pilot study, we have extended this in vitro observation and examined cofilin phosphorylation in
resting CD4 T cells purified from the peripheral blood of HIV-1-infected patients. Here, we report
that the resting T cells from infected patients carry significantly higher levels of active cofilin,
suggesting that these resting cells have been primed in vivo in cofilin activity to facilitate HIV-1
infection. HIV-1-mediated aberrant activation of cofilin may also lead to abnormalities in T cell
migration and activation that could contribute to viral pathogenesis. | |
Item Format | PDF | |
Item Language | en_US | |
Rights | Attribution-NonCommercial 4.0 United States | |
Rights URL | https://creativecommons.org/licenses/by/4.0/ | |
Title | Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients: a pilot study. | |
Type | Article | |
Identifier (DOI) | 10.1186/1742-4690-5-95 | |