may not work without it.
If you have any problems related to the accessibility of any content (or if you want to request that a specific publication be accessible), please contact (email@example.com). We will work to respond to each request in as timely a manner as possible.
Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients: a pilot study.
Cofilin is an actin-depolymerizing factor that regulates actin dynamics critical for T cell migration
and T cell activation. In unstimulated resting CD4 T cells, cofilin exists largely as a phosphorylated
inactive form. Previously, we demonstrated that during HIV-1 infection of resting CD4 T cells, the
viral envelope-CXCR4 signaling activates cofilin to overcome the static cortical actin restriction. In
this pilot study, we have extended this in vitro observation and examined cofilin phosphorylation in
resting CD4 T cells purified from the peripheral blood of HIV-1-infected patients. Here, we report
that the resting T cells from infected patients carry significantly higher levels of active cofilin,
suggesting that these resting cells have been primed in vivo in cofilin activity to facilitate HIV-1
infection. HIV-1-mediated aberrant activation of cofilin may also lead to abnormalities in T cell
migration and activation that could contribute to viral pathogenesis.