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Nm23-H1 modulates the activity of the guanine exchange factor Dbl-1
Cytoskeleton rearrangement is necessary for tumor invasion and metastasis. Cellular molecules whose role is to regulate components of the cytoskeletal structure can dictate changes in cellular morphology. One of these ...
Epstein-Barr virus proteins can upregulate cyclo-oxygenase-2 expression through association with the suppressor of metastasis Nm23-H1
Epstein–Barr virus (EBV) is a lymphotrophic herpesvirus infecting most of the world's population. It is associated with a number of human lymphoid and epithelial tumors and lymphoproliferative diseases in immunocompromised ...
Latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus interacts with origin recognition complexes at the LANA binding sequence within the terminal repeats.
Kaposi's sarcoma-associated herpesvirus (KSHV) DNA persists in latently infected cells as an episome via tethering to the host chromosomes. The latency-associated nuclear antigen (LANA) of KSHV binds to the cis-acting ...
Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein.
Deregulation of the evolutionarily conserved Notch signaling is highly correlated with oncogenesis. Intracellular activated Notch (ICN) is a protooncogene linked to the transcription activation of a number of cellular genes ...
Protein complexes associated with the Kaposi's sarcoma-associated herpesvirus-encoded LANA.
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the major biological cofactor contributing to development of Kaposi’s sarcoma. KSHV establishes a latent infection in human B cells expressing the latency-associated nuclear ...