Recent Submissions

  • .

    .

    .

    New Biomarkers of Innate and Adaptive Immunity in Infectious Diseases 

    Morzunov, Sergey; Deyde, Varough; Abrahamyan, Levon (Journal of Immunology Research, 2017)
    We invited prospective authors to contribute original manuscripts, case reports, clinical trials, and reviews focusing on genetic aberrations, cytokines, growth factors, and other small biologically active molecules as ...
  • .

    .

    .

    HHV-6A Infection of Endometrial Epithelial Cells Induces Increased Endometrial NK Cell-Mediated Cytotoxicity 

    Caselli, Elisabetta; Bortolotti, Daria; Marci, Roberto; Rotola, Antonella; Gentili, Valentina; Soffritti, Irene; D'Accolti, Maria; Lo Monte, Giuseppe; Sicolo, Mariangela; Barao, Isabel; Di Luca, Dario; Rizzo, Roberta (Frontiers in Microbiology, 2017)
    We have recently reported the presence of Human herpesvirus-6A (HHV6A) DNA in the 43% of endometrial epithelial cells from primary idiopathic infertile women, with no positivity in fertile women. To investigate the possible ...
  • .

    .

    .

    Genome-scale analysis of the genes that contribute to Burkholderia pseudomallei biofilm formation identifies a crucial exopolysaccharide biosynthesis gene cluster 

    Borlee, Grace I.; Plumley, Brooke A.; Martin, Kevin H.; Somprasong, Nawarat; Mangalea, Mihnea R.; Islam, M. Nurul; Burtnick, Mary N.; Brett, Paul J.; Steinmetz, Ivo; AuCoin, David P.; Belisle, John T.; Crick, Dean C.; Schweizer, Herbert P.; Borlee, Bradley R. (2017)
    Burkholderia pseudomallei, the causative agent of melioidosis, is an important public health threat due to limited therapeutic options for treatment. Efforts to improve therapeutics for B. pseudomallei infections are ...
  • .

    .

    .

    Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome 

    Khaiboullina, Svetlana F.; Levis, Silvana; Morzunov, Sergey P.; Martynova, Ekaterina V.; Anokhin, Vladimir A.; Gusev, Oleg A.; St Jeor, Stephen C.; Lombardi, Vincent C.; Rizvanov, Albert A. (2017)
    Hantavirus infection is an acute zoonosis that clinically manifests in two primary forms, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). HFRS is endemic in Europe and Russia, where ...
  • .

    .

    .

    Conservation of Mannan Synthesis in Fungi of the Zygomycota and Ascomycota Reveals a Broad Diagnostic Target 

    Burnham-Marusich, Amanda R.; Hubbard, Breeana; Kvam, Alexander J.; Gates-Hollingsworth, Marcellene; Green, Heather R.; Soukup, Eric; Limper, Andrew H.; Kozel, Thomas R. (2018)
    Ascomycetes and zygomycetes account for the majority of (i) fungi responsible for cutaneous, subcutaneous, and invasive human fungal infections, (ii) plant fungal pathogens, (iii) fungi that threaten global biodiversity, ...
  • .

    .

    .

    Recombinant Viruses for Cancer Therapy 

    Chulpanova, Daria S.; Solovyeva, Valeriya V.; Kitaeva, Kristina V.; Dunham, Stephen P.; Khaiboullina, Svetlana F.; Rizvanov, Albert A. (2018)
    Recombinant viruses are novel therapeutic agents that can be utilized for treatment of various diseases, including cancers. Recombinant viruses can be engineered to express foreign transgenes and have a broad tropism ...
  • .

    .

    .

    History of ZIKV Infections in India and Management of Disease Outbreaks 

    Khaiboullina, Svetalana; Uppal, Timsy; Martynova, Ekaterina; Rizvanov, Albert; Baranwal, Manoj; Verma, Subhash C. (2018)
    Zika virus (ZIKV) is an emerging arbovirus infection endemic in multiple countries spread from Asia, Africa to the Americas and Europe. Previously known to cause rare and fairly benign human infections, ZIKV has become a ...
  • .

    .

    .

    Immunoglobulin G subclass switching impacts sensitivity of an immunoassay targeting Francisella tularensis Iipopolysaccharide 

    Nualnoi, Teerapat; Kirosingh, Adam; Basallo, Kaitlin; Hau, Derrick; Gates-Hollingsworth, Marcellene A.; Thorkildson, Peter; Crump, Reva B.; Reed, Dana E.; Pandit, Sujata; AuCoin, David P. (2018)
    The CDC Tier 1 select agent Francisella tularensis is a small, Gram-negative bacterium and the causative agent of tularemia, a potentially life-threatening infection endemic in the United States, Europe and Asia. Currently, ...
  • .

    .

    .

    Immune response to recombinant Burkholderia pseudomallei FIiC 

    Koosakulnirand, Sirikamon; Phokrai, Phornpun; Jenjaroen, Kemajittra; Roberts, Rosemary A.; Utaisincharoen, Pongsak; Dunachie, Susanna J.; Brett, Paul J.; Burtnick, Mary N.; Chantratita, Narisara (2018)
    Burkholderia pseudomallei is a flagellated Gram-negative bacterium which is the causative agent of melioidosis. The disease poses a major public health problem in tropical regions and diabetes is a major risk factor. The ...
  • .

    .

    .

    A Rapid Immunochromatography Test Based on Hcp1 Is a Potential Point-of-Care Test for Serological Diagnosis of Melioidosis 

    Phokrai, Phornpun; Karoonboonyanan, Wisansanee; Thanapattarapairoj, Nida; Promkong, Chidchanok; Dulsuk, Adul; Koosakulnirand, Sirikamon; Canovali, Sasha; Indrawattana, Nitaya; Jutrakul, Yaowaruk; Wuthiekanun, Vanaporn; Limmathurotsakul, Direk; Brett, Paul J.; Burtnick, Mary N.; Lertmemongkolchai, Ganjana; Chantratita, Narisara (2018)
    Melioidosis is a fatal infectious disease caused by the environmental bacterium Burkholderia pseudomallei. It is highly endemic in Asia and northern Australia but neglected in many other tropical countries. Melioidosis ...
  • .

    .

    .

    Sensitivity and specificity of a lateral flow immunoassay (LFI) in serum samples for diagnosis of melioidosis 

    Wongsuvan, Gumphol; Hantrakun, Viriya; Teparrukkul, Prapit; Imwong, Mallika; West, T. Eoin; Wuthiekanun, Vanaporn; Day, Nicholas P. J.; AuCoin, David; Limmathurotsakul, Direk (2018)
    Culture is the gold standard for the diagnosis of melioidosis, an infection caused by Burkholderia pseudomallei. Here we evaluate a lateral flow immunoassay (LFI) to detect B. pseudomallei capsular polysaccharide (CPS) in ...
  • .

    .

    .

    KSHV encoded ORF59 modulates histone arginine methylation of the viral genome to promote viral reactivation 

    Strahan, Roxanne C.; McDowell-Sargent, Maria; Uppal, Timsy; Purushothaman, Pravinkumar; Verma, Subhash C. (2017)
    Kaposi's sarcoma associated herpesvirus (KSHV) persists in a highly-ordered chromatin structure inside latently infected cells with the majority of the viral genome having repressive marks. However, upon reactivation the ...
  • .

    .

    .

    Deciphering minimal antigenic epitopes associated with Burkholderia pseudomallei and Burkholderia mallei lipopolysaccharide O-antigens 

    Kenfack, Marielle Tamigney; Mazur, Marcelina; Nualnoi, Teerapat; Shaffer, Teresa L.; Ngassimou, Abba; Bleriot, Yves; Marrot, Jerome; Marchetti, Roberta; Sintiprungrat, Kitisak; Chantratita, Narisara; Silipo, Alba; Molinaro, Antonio; AuCoin, David P.; Burtnick, Mary N.; Brett, Paul J.; Gauthier, Charles (2017)
    Burkholderia pseudomallei (Bp) and Burkholderia mallei (Bm), the etiologic agents of melioidosis and glanders, respectively, cause severe disease in both humans and animals. Studies have highlighted the importance of Bp ...
  • .

    .

    .

    Clinical efficacy, Safety, and immunogenicity of a Live Attenuated Tetravalent Dengue vaccine (CYD-TDv) in Children: A Systematic Review with Meta-analysis 

    Malisheni, Moffat; Khaiboullina, Svetlana F.; Rizvanov, Albert A.; Takah, Noah; Murewanhema, Grant; Bates, Matthew (2017)
    Dengue hemorrhagic fever is the leading cause of hospitalization and death in children living in Asia and Latin America. There is an urgent need for an effective and safe dengue vaccine to reduce morbidity and mortality ...
  • .

    .

    .

    Evaluation of four clinical laboratory parameters for the diagnosis of myalgic encephalomyelitis 

    De Meirleir, Kenny L.; Mijatovic, Tatjana; Subramanian, Krishnamurthy; Schlauch, Karen A.; Lombardi, Vincent C. (2018)
    Myalgic encephalomyelitis (ME) is a complex and debilitating disease that often initially presents with flu-like symptoms, accompanied by incapacitating fatigue. Currently, there are no objective biomarkers or laboratory ...
  • .

    .

    .

    Development of Immunoassays for Burkholderia pseudomallei Typical and Atypical Lipopolysaccharide Strain Typing 

    Nualnoi, Teerapat; Norris, Michael H.; Tuanyok, Apichai; Brett, Paul J.; Burtnick, Mary N.; Keim, Paul S.; Settles, Erik W.; Allender, Christopher J.; AuCoin, David P. (2017)
    Burkholderia pseudomallei is the causative agent of melioidosis, a severe infection endemic to many tropical regions. Lipopolysaccharide (LPS) is recognized as an important virulence factor used by B. pseudomallei. Isolates ...
  • .

    .

    .

    When is cough functional, and how should it be treated? 

    Weinberger, Miles; Lockshin, Boris (2017)
    Involuntary cough without an identified underlying organic reason has been given various names and recommended treatments. Current experience in children and adolescents suggests that "habit cough" best describes this ...
  • .

    .

    .

    Role of Pattern Recognition Receptors in KSHV Infection 

    Uppal, Timsy; Sarkar, Roni; Dhelaria, Ranjit; Verma, Subhash C. (2018)
    Kaposi's sarcoma-associated herpesvirus or Human herpesvirus-8 (KSHV/HHV-8), an oncogenic human herpesvirus and the leading cause of cancer in HIV-infected individuals, is a major public health concern with recurring reports ...
  • .

    .

    .

    The Interplay between Natural Killer Cells and Human Herpesvirus-6 

    Eliassen, Eva; Di Luca, Dario; Rizzo, Roberta; Barao, Isabel (2017)
    Human Herpesvirus 6 (HHV-6) is a set of two closely related herpes viruses known as HHV-6A and HHV-6B. Both are lymphotropic viruses that establish latency in the host. The ability to evade the immune responses of effector ...
  • .

    .

    .

    Development of Subunit Vaccines That Provide High-Level Protection and Sterilizing Immunity against Acute Inhalational Melioidosis 

    Burtnick, Mary N.; Shaffer, Teresa L.; Ross, Brittany N.; Muruato, Laura A.; Sbrana, Elena; DeShazer, David; Torres, Alfredo G.; Brett, Paul J. (2018)
    Burkholderia pseudomallei, the etiologic agent of melioidosis, causes severe disease in humans and animals. Diagnosis and treatment of melioidosis can be challenging, and no licensed vaccines currently exist. Several studies ...

View more