Now showing items 21-40 of 114

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    Multiplex analysis of serum cytokines in humans with hantavirus pulmonary syndrome 

    Morzunov, Sergey P.; Khaiboullina, Svetlana F.; St Jeor, Stephen; Rizvanov, Albert A.; Lombardi, Vincent C. (Frontiers in Immunology, 2015)
    Hantavirus pulmonary syndrome (HPS) is an acute zoonotic disease transmitted primarily through inhalation of virus-contaminated aerosols. Hantavirus infection of endothelial cells leads to increased vascular permeability ...
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    Microparticulate beta-glucan vaccine conjugates phagocytized by dendritic cells activate both naive CD4 and CD8 T cells in vitro 

    Berner, Vanessa K.; DuPré, Sally A.; Redelman, Doug; Hunter, Kenneth W. (Cellular Immunology, 2015)
    Microparticulate beta-glucan (MG) conjugated to vaccine antigen has been shown to serve as an effective adjuvant in vivo. To further study antigen presentation by MG: vaccine conjugates, bone marrow-derived dendritic cells ...
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    Recombinant of PUUV genome S segment isolated from rodents captured in the Republic of Tatarstan, Russia 

    Kabwe, E.; Davidyuk, Yuriy N.; Morzunov, Sergey P.; Martynova, Ekaterina V.; Garanina, Ekaterina E.; Ismagilova, R. K.; Khaiboullina, Svetlana F.; Rizvanov, A. A. (International Journal of Infectious Diseases, 2019)
    Puumala hantavirus (PUUV) is the main cause of hemorrhagic fever with renal syndrome (HRFS) in Russia. Although known to cause HFRS endemic in the Republic of Tatarstan (RT), little is known about the genetic diversity of ...
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    Hantavirus Puumala genetic variation in the patients with HFRS in Tatarstan, Russia 

    Kabwe, E.; Davidyuk, Yuriy N.; Morzunov, Sergey P.; Martynova, Ekaterina V.; Garanina, Ekaterina E.; Shakirova, V. G.; Ismagilova, R. K.; Khaiboullina, Svetlana F.; Rizvanov, A. A. (International Journal of Infectious Diseases, 2019)
    Puumala hantavirus (PUUV) can cause hemorrhagic fever with renal syndrome (HFRS), an acute infection characterized by hemorrhages and kidney insufficiency. The Volga Federal District, including the Republic of Tatarstan ...
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    New Biomarkers of Innate and Adaptive Immunity in Infectious Diseases 

    Morzunov, Sergey P.; Deyde, Varough; Abrahamyan, Levon (Journal of Immunology Research, 2017)
    We invited prospective authors to contribute original manuscripts, case reports, clinical trials, and reviews focusing on genetic aberrations, cytokines, growth factors, and other small biologically active molecules as ...
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    HHV-6A Infection of Endometrial Epithelial Cells Induces Increased Endometrial NK Cell-Mediated Cytotoxicity 

    Caselli, Elisabetta; Bortolotti, Daria; Marci, Roberto; Rotola, Antonella; Gentili, Valentina; Soffritti, Irene; D'Accolti, Maria; Lo Monte, Giuseppe; Sicolo, Mariangela; Barao, Isabel; Di Luca, Dario; Rizzo, Roberta (Frontiers in Microbiology, 2017)
    We have recently reported the presence of Human herpesvirus-6A (HHV6A) DNA in the 43% of endometrial epithelial cells from primary idiopathic infertile women, with no positivity in fertile women. To investigate the possible ...
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    Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome 

    Khaiboullina, Svetlana F.; Levis, Silvana; Morzunov, Sergey P.; Martynova, Ekaterina V.; Anokhin, Vladimir A.; Gusev, Oleg A.; St Jeor, Stephen C.; Lombardi, Vincent C.; Rizvanov, Albert A. (2017)
    Hantavirus infection is an acute zoonosis that clinically manifests in two primary forms, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). HFRS is endemic in Europe and Russia, where ...
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    Recombinant Viruses for Cancer Therapy 

    Chulpanova, Daria S.; Solovyeva, Valeriya V.; Kitaeva, Kristina V.; Dunham, Stephen P.; Khaiboullina, Svetlana F.; Rizvanov, Albert A. (2018)
    Recombinant viruses are novel therapeutic agents that can be utilized for treatment of various diseases, including cancers. Recombinant viruses can be engineered to express foreign transgenes and have a broad tropism ...
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    Sensitivity and specificity of a lateral flow immunoassay (LFI) in serum samples for diagnosis of melioidosis 

    Wongsuvan, Gumphol; Hantrakun, Viriya; Teparrukkul, Prapit; Imwong, Mallika; West, T. Eoin; Wuthiekanun, Vanaporn; Day, Nicholas P. J.; AuCoin, David P.; Limmathurotsakul, Direk (2018)
    Culture is the gold standard for the diagnosis of melioidosis, an infection caused by Burkholderia pseudomallei. Here we evaluate a lateral flow immunoassay (LFI) to detect B. pseudomallei capsular polysaccharide (CPS) in ...
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    Genome-scale analysis of the genes that contribute to Burkholderia pseudomallei biofilm formation identifies a crucial exopolysaccharide biosynthesis gene cluster 

    Borlee, Grace I.; Plumley, Brooke A.; Martin, Kevin H.; Somprasong, Nawarat; Mangalea, Mihnea R.; Islam, M. Nurul; Burtnick, Mary N.; Brett, Paul J.; Steinmetz, Ivo; AuCoin, David P.; Belisle, John T.; Crick, Dean C.; Schweizer, Herbert P.; Borlee, Bradley R. (2017)
    Burkholderia pseudomallei, the causative agent of melioidosis, is an important public health threat due to limited therapeutic options for treatment. Efforts to improve therapeutics for B. pseudomallei infections are ...
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    A Rapid Immunochromatography Test Based on Hcp1 Is a Potential Point-of-Care Test for Serological Diagnosis of Melioidosis 

    Phokrai, Phornpun; Karoonboonyanan, Wisansanee; Thanapattarapairoj, Nida; Promkong, Chidchanok; Dulsuk, Adul; Koosakulnirand, Sirikamon; Canovali, Sasha; Indrawattana, Nitaya; Jutrakul, Yaowaruk; Wuthiekanun, Vanaporn; Limmathurotsakul, Direk; Brett, Paul J.; Burtnick, Mary N.; Lertmemongkolchai, Ganjana; Chantratita, Narisara (2018)
    Melioidosis is a fatal infectious disease caused by the environmental bacterium Burkholderia pseudomallei. It is highly endemic in Asia and northern Australia but neglected in many other tropical countries. Melioidosis ...
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    Immune response to recombinant Burkholderia pseudomallei FIiC 

    Koosakulnirand, Sirikamon; Phokrai, Phornpun; Jenjaroen, Kemajittra; Roberts, Rosemary A.; Utaisincharoen, Pongsak; Dunachie, Susanna J.; Brett, Paul J.; Burtnick, Mary N.; Chantratita, Narisara (2018)
    Burkholderia pseudomallei is a flagellated Gram-negative bacterium which is the causative agent of melioidosis. The disease poses a major public health problem in tropical regions and diabetes is a major risk factor. The ...
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    Immunoglobulin G subclass switching impacts sensitivity of an immunoassay targeting Francisella tularensis Iipopolysaccharide 

    Nualnoi, Teerapat; Kirosingh, Adam; Basallo, Kaitlin; Hau, Derrick; Gates-Hollingsworth, Marcellene A.; Thorkildson, Peter; Crump, Reva B.; Reed, Dana E.; Pandit, Sujata G.; AuCoin, David P. (2018)
    The CDC Tier 1 select agent Francisella tularensis is a small, Gram-negative bacterium and the causative agent of tularemia, a potentially life-threatening infection endemic in the United States, Europe and Asia. Currently, ...
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    Conservation of Mannan Synthesis in Fungi of the Zygomycota and Ascomycota Reveals a Broad Diagnostic Target 

    Burnham-Marusich, Amanda R.; Hubbard, Breeana N.; Kvam, Alexander J.; Gates-Hollingsworth, Marcellene A.; Green, Heather R.; Soukup, Eric; Limper, Andrew H.; Kozel, Thomas R. (2018)
    Ascomycetes and zygomycetes account for the majority of (i) fungi responsible for cutaneous, subcutaneous, and invasive human fungal infections, (ii) plant fungal pathogens, (iii) fungi that threaten global biodiversity, ...
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    History of ZIKV Infections in India and Management of Disease Outbreaks 

    Khaiboullina, Svetlana F.; Uppal, Timsy; Martynova, Ekaterina V.; Rizvanov, Albert; Baranwal, Manoj; Verma, Subhash C. (2018)
    Zika virus (ZIKV) is an emerging arbovirus infection endemic in multiple countries spread from Asia, Africa to the Americas and Europe. Previously known to cause rare and fairly benign human infections, ZIKV has become a ...
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    When is cough functional, and how should it be treated? 

    Weinberger, Miles; Lockshin, Boris (2017)
    Involuntary cough without an identified underlying organic reason has been given various names and recommended treatments. Current experience in children and adolescents suggests that "habit cough" best describes this ...
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    Clinical efficacy, Safety, and immunogenicity of a Live Attenuated Tetravalent Dengue vaccine (CYD-TDv) in Children: A Systematic Review with Meta-analysis 

    Malisheni, Moffat; Khaiboullina, Svetlana F.; Rizvanov, Albert A.; Takah, Noah; Murewanhema, Grant; Bates, Matthew (2017)
    Dengue hemorrhagic fever is the leading cause of hospitalization and death in children living in Asia and Latin America. There is an urgent need for an effective and safe dengue vaccine to reduce morbidity and mortality ...
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    KSHV encoded ORF59 modulates histone arginine methylation of the viral genome to promote viral reactivation 

    Strahan, Roxanne C.; McDowell-Sargent, Maria; Uppal, Timsy; Purushothaman, Pravinkumar; Verma, Subhash C. (2017)
    Kaposi's sarcoma associated herpesvirus (KSHV) persists in a highly-ordered chromatin structure inside latently infected cells with the majority of the viral genome having repressive marks. However, upon reactivation the ...
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    Development of Immunoassays for Burkholderia pseudomallei Typical and Atypical Lipopolysaccharide Strain Typing 

    Nualnoi, Teerapat; Norris, Michael H.; Tuanyok, Apichai; Brett, Paul J.; Burtnick, Mary N.; Keim, Paul S.; Settles, Erik W.; Allender, Christopher J.; AuCoin, David P. (2017)
    Burkholderia pseudomallei is the causative agent of melioidosis, a severe infection endemic to many tropical regions. Lipopolysaccharide (LPS) is recognized as an important virulence factor used by B. pseudomallei. Isolates ...
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    Evaluation of four clinical laboratory parameters for the diagnosis of myalgic encephalomyelitis 

    De Meirleir, Kenny L.; Mijatovic, Tatjana; Subramanian, Krishnamurthy; Schlauch, Karen A.; Lombardi, Vincent C. (2018)
    Myalgic encephalomyelitis (ME) is a complex and debilitating disease that often initially presents with flu-like symptoms, accompanied by incapacitating fatigue. Currently, there are no objective biomarkers or laboratory ...