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Single Molecule Analysis of Replicated DNA Reveals the Usage of Multiple KSHV Genome Regions for Latent Replication.
Kaposi's sarcoma associated herpesvirus (KSHV), an etiologic agent of Kaposi's sarcoma, Body Cavity Based Lymphoma and Multicentric Castleman's Disease, establishes lifelong latency in infected cells. The KSHV genome tethers ...
Co-infections and Pathogenesis of KSHV-Associated Malignancies
Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as human herpes virus 8 (HHV-8) is one of the several carcinogenic viruses that infect humans. KSHV infection has been implicated in the development of Kaposi’s ...
Protein complexes associated with the Kaposi's sarcoma-associated herpesvirus-encoded LANA.
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the major biological cofactor contributing to development of Kaposi’s sarcoma. KSHV establishes a latent infection in human B cells expressing the latency-associated nuclear ...
Molecular genetics of herpesviruses: a recombinant technology approach.
Herpesvirus genetics have long been hindered by the large size of the typical herpesvirus genome and the consequent recalcitrance of these genomes to manipulation by standard molecular genetics techniques. However, two ...
Proteomic analysis of the Kaposi's sarcoma-associated herpesvirus terminal repeat element-binding proteins.
Terminal repeat (TR) elements of Kaposi's sarcoma-associated herpesvirus (KSHV), the potential origin sites of KSHV replication, have been demonstrated to play important roles in viral replication and transcription and are ...
Early events associated with infection of Epstein-Barr virus infection of primary B-cells.
Epstein Barr virus (EBV) is closely associated with the development of a vast number of human cancers. To develop a system for monitoring early cellular and viral events associated with EBV infection a self-recombining BAC ...
The RBP-J? binding sites within the RTA Promoter Regulates KSHV Latent Infection and Proliferation
Kaposi's sarcoma-associated herpesvirus (KSHV) is tightly linked to at least two lymphoproliferative disorders, primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). However, the development of ...
EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors
Cellular protein degradation pathways can be utilized by viruses to establish an environment that favors their propagation. Here we report that the Kaposi's sarcoma–associated herpesvirus (KSHV)-encoded latency-associated ...
Comprehensive Analysis of LANA Interacting Proteins Essential for Viral Genome Tethering and Persistence
Kaposi’s sarcoma associated herpesvirus is tightly linked to multiple human malignancies including Kaposi’s sarcoma (KS), Primary Effusion Lymphoma (PEL) and Multicentric Castleman’s Disease (MCD). KSHV like other herpesviruses ...