Threat of Carbapenem Resistant Enterobacteriaceae and the Rise of Antibiotic Resistance
AuthorStaffa, Nicholas Charles
Molecular Microbiology and Immunology
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Antibiotic resistance is no new phenomenon. Evidenced by the presence of intrinsic resistance, microbes have had mechanisms to subvert antimicrobials for a very long time. Improper and poor use of antibiotics has further exacerbated the prevalence of antibiotic resistance in the microbial world, posing a significant threat to human health. Among these antibiotic resistant microbes, Carbapenem Resistant Enterobacteriaceae (CRE) are of particular concern. CRE infections have a relative mortality rate of 50% (Guh et al., 2013). While containing Carbapenem inactivating enzymes, horizontal gene transfer is a powerful force influencing virulence of CRE. Several other factors have led to the current, dire state of antibiotic resistance: frequent and improper use of antibiotics, minimal understanding of fundamental microbiological principles, and lack of focus on unification under a common purpose. International impact necessitates a multifaceted approach focusing on cooperative, and unified efforts.