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Crohn’s Disease: NF-?? Activity Caused by NOD2 Signal Transduction and Increased by NOD2 Mutation and a Clinical Case Study
Date
2015Type
ThesisDepartment
Biochemistry and Molecular Biology
Degree Level
Honors Thesis
Degree Name
Biochem and Molecular Biology
Abstract
Crohn’s disease is a chronic inflammatory bowel disease that can affect any part of the
gastrointestinal tract from the mouth to anus. The cause of the disease is still unknown,
but scientists have found various genetic mutations that are believed to play a role in the
pathogenesis of the disease. One of these mutations include the NOD2 protein. Research
has been conducted to shed light on the NOD2 signal transduction pathway and its
involvement in NF-?B activation, a transcription factor that activates the production of
various cytokines and chemokines that cause inflammation. By understanding this
pathway and its relation to Crohn’s disease, drugs can be developed for more effective
treatment. The general background of Crohn’s disease will be outlined including its
symptoms, clinical features, epidemiology, and treatment. Chapter 2 is a literature review
of research regarding the NOD2 pathway and the effects of NOD2 mutation in the
activation of NF-?B. Finally, a model clinical case study will be reviewed in which the
diagnosis and treatment of a Crohn’s disease patient are explained.
Permanent link
http://hdl.handle.net/11714/647Additional Information
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