If you have any problems related to the accessibility of any content (or if you want to request that a specific publication be accessible), please contact us at scholarworks@unr.edu.
Polycystic Kidney Disease: Literature Review on the Mechanism of Mammalian Target of Rapamycin (mTOR) Inhibitors in the Reduction of Cyst Growth in Patients with ADPKD and a Clinical Case Study
Date
2014Type
ThesisDepartment
Biochemistry and Molecular Biology
Degree Level
Honors Thesis
Degree Name
Biochem and Molecular Biology
Abstract
Polycystic Kidney Disease (PKD) is a genetic disorder characterized by a growth
of multiple cysts in the kidney which, in most cases, culminates in end stage renal failure.
A clinical case study was done to highlight the clinical manifestations and the
progression of Autosomal Dominant Polycystic Kidney Disease (ADPKD). Currently
there are no treatments or cures for PKD with the exception of dialysis and kidney
transplantation for patients in kidney failure. Exploration of the role of PKD1 and PKD2
in cystogenesis had yielded potential treatment alternatives for ADPKD such as the use
of mammalian target of rapamycin (mTOR) inhibitors to reduce cyst growth and preserve
kidney function.
Permanent link
http://hdl.handle.net/11714/634Additional Information
Rights | In Copyright(All Rights Reserved) |
---|---|
Rights Holder | Author(s) |