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A Single-Subject Method to Detect Pathways Enriched With Alternatively Spliced Genes
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Participants in White et al.’s (1) study performed a semantic categorization task while viewing pairs of words presented simultaneously to the right and left of fixation. On each trial, participants viewed two briefly displayed words (nouns), one displayed to the left of fixation, and the other to the right of fixation, and categorized one of the words as either living or nonliving. In a “focal cue” condition, participants performed the task on either the left or the right word, according to a precue. In a “distributed cue” condition, participants paid attention to both words and subsequently reported the semantic category of one of the words, but without knowing which in advance. The authors, in a previous behavioral study (2), used a similar task to show that even highly skilled readers are able to recognize only one word at a time. In the current study, participants performed the task during fMRI scanning, which measures blood oxygen level-dependent (BOLD) signals with millimeter-level spatial resolution.