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Towards an Understanding of Alterations in the Expression Profile of the ADL olfactory neuron of Caenorhabditis elegans as a Function of Feeding State
AuthorKoontz, Austin C.
Advisorvan der Linden, Alexander M.
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Olfaction is adjusted in many organisms in response to changes feeding state. The proposed study intends to describe a method of investigating the molecular mechanisms involved in changes in olfactory perception as a function of feeding-state in the model organism Caenorhabditis elegans, a system characterized by an expansive understanding of important genetic and neural networks. Alterations in gene expression in the olfactory neuron due to feeding state will be characterized using molecular techniques and next-generation sequencing. Such an understanding of these mechanisms could be utilized to prevent infection of human hosts by parasitic nematodes and other parasites as well.