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Role of NanA in Bacterial Meningitis and a Model Case Study
AdvisorBaker, Josh E.
Biochemistry and Molecular Biology
Biochem and Molecular Biology
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Bacterial Meningitis is a debilitating and potentially life threatening bacterial infection of the spinal fluid and meninges of the brain. While the exact mechanism used by bacteria to pass into the otherwise isolated spinal fluid is not fully understood, it is known that NanA plays a crucial role in this process. The goal of this thesis is to describe the enzymatic function of NanA and how it relates to bacterial adhesion and transportation. A case study of a 6 year-old child is included to demonstrate the rapid onset of symptoms in bacterial meningitis and its severity.