A germ-line deletion of APOBEC3B does not contribute to subtype-specific childhood acute lymphoblastic leukemia etiology

Abstract

Approximately 4/100,000 children are diagnosed with acute lymphoblastic leukemia (ALL) in the United States annually. Early life exposures related to immune priming (i.e. vaginal birth, daycare attendance, and high birth order)1 and having fewer infections requiring medical treatment2 have been inversely associated with disease, suggesting an etiological role of infectious a