Macrocyclic Polyamines and Their Metal Complexes Targeting HIV-1
AuthorPearce, Alexandra Rene
AdvisorBell, Thomas W.
ChemistryMathematics & Statistics
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M40401 is a well known antioxidant and as of late, it has been studied for anti- HIV properties. It was reported to reduce apoptosis of astrocytes caused by HIV- 1 infected macrophages (M/M) supernatants, and in 2005, a poster presented at the International Conference for Antiviral Research claimed that HIV-1 replication was reduced in infected M/M when treated with M40401. Our goal is to synthesize M40403, a similar molecule, as well as other related molecules for further study. M40403 and previously synthesized related molecules have been shown to have anti-HIV properties. We will synthesize more related molecules in an attempt to maximize the ratio of potency to toxicity. Hopefully by tweaking the molecules, we will find one that can eventually be made into a drug to help the fight against HIV-1.