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Browsing Physiology and Cell Biology - Faculty Research by Issue Date
Now showing items 1-20 of 83
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Role of Telokin in Regulating Murine Gastric Fundus Smooth Muscle Tension
(2015)Telokin phosphorylation by cyclic GMP-dependent protein kinase facilitates smooth muscle relaxation. In this study we examined the relaxation of gastric fundus smooth muscles from basal tone, or pre-contracted with KCl or ... -
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Escape of X-linked miRNA genes from meiotic sex chromosome inactivation
(2015)Past studies have indicated that transcription of all X-linked genes is repressed by meiotic sex chromosome inactivation (MSCI) during the meiotic phase of spermatogenesis in mammals. However, more recent studies have shown ... -
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Dynamic transcriptional symmetry-breaking in pre-implantation mammalian embryo development revealed by single-cell RNA-seq
(2015)During mammalian pre-implantation embryo development, when the first asymmetry emerges and how it develops to direct distinct cell fates remain longstanding questions. Here, by analyzing single-blastomere transcriptome ... -
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Renal medullary (pro)renin receptor contributes to angiotensin II-induced hypertension in rats via activation of the local renin-angiotensin system
(2015)(Pro) renin receptor (PRR) is a new component of the renin-angiotensin system and regulates renin activity in vitro. Within the kidney, PRR is highly expressed in the renal medulla where its expression is induced by ... -
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Microparticulate beta-glucan vaccine conjugates phagocytized by dendritic cells activate both naive CD4 and CD8 T cells in vitro
(Cellular Immunology, 2015)Microparticulate beta-glucan (MG) conjugated to vaccine antigen has been shown to serve as an effective adjuvant in vivo. To further study antigen presentation by MG: vaccine conjugates, bone marrow-derived dendritic cells ... -
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Smooth Muscle Cell Genome Browser: Enabling the Identification of Novel Serum Response Factor Target Genes
(2015)Genome-scale expression data on the absolute numbers of gene isoforms offers essential clues in cellular functions and biological processes. Smooth muscle cells (SMCs) perform a unique contractile function through expression ... -
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Pervasive Genotypic Mosaicism in Founder Mice Derived from Genome Editing through Pronuclear Injection
(2015)Genome editing technologies, especially the Cas9/CRISPR system, have revolutionized biomedical research over the past several years. Generation of novel alleles has been simplified to unprecedented levels, allowing for ... -
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Use of Genetically Encoded Calcium Indicators (GECIs) Combined with Advanced Motion Tracking Techniques to Examine the Behavior of Neurons and Glia in the Enteric Nervous System of the Intact Murine Colon
(2015)Genetically encoded Ca2+ indicators (GEC's) have been used extensively in many body systems to detect Ca2+ transients associated with neuronal activity. Their adoption in enteric neurobiology has been slower, although they ... -
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Prediction of junior faculty success in biomedical research: comparison of metrics and effects of mentoring programs
(2015)Measuring and predicting the success of junior faculty is of considerable interest to faculty, academic institutions, funding agencies and faculty development and mentoring programs. Various metrics have been proposed to ... -
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Visceral Hypersensitivity and Altered Colonic Motility in Type 2 Diabetic Rat
(2015)Abnormal visceral sensitivity and disordered motility are common in patients with diabetes mellitus. The purpose of the present study was to investigate whether visceral sensation and bowel motility were altered in a rat ... -
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Serum Response Factor Is Essential for Prenatal Gastrointestinal Smooth Muscle Development and Maintenance of Differentiated Phenotype
(2015)Smooth muscle cells (SMCs) characteristically express serum response factor (SRF), which regulates their development. The role of SRF in SMC plasticity in the pathophysiological conditions of gastrointestinal (GI) tract ... -
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Measuring Gastrointestinal Electrical Activity With Extracellular Electrodes: Author's Reply
(2015)Letter to the Editor -
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Loss of serum response factor induces microRNA-mediated apoptosis in intestinal smooth muscle cells
(2015)Serum response factor (SRF) is a transcription factor known to mediate phenotypic plasticity in smooth muscle cells (SMCs). Despite the critical role of this protein in mediating intestinal injury response, little is known ... -
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Ancestral vinclozolin exposure alters the epigenetic transgenerational inheritance of sperm small noncoding RNAs
(2016)Exposure to the agricultural fungicide vinclozolin during gestation promotes a higher incidence of various diseases in the subsequent unexposed F3 and F4 generations. This phenomenon is termed epigenetic transgenerational ... -
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A Novel Striated Muscle-Specific Myosin-Blocking Drug for the Study of Neuromuscular Physiology
(2016)The failure to transmit neural action potentials (APs) into muscle APs is referred to as neuromuscular transmission failure (NTF). Although synaptic dysfunction occurs in a variety of neuromuscular diseases and impaired ... -
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Expression profiling elucidates a molecular gene signature for pulmonary hypertension in sarcoidosis
(2016)Pulmonary hypertension (PH), when it complicates sarcoidosis, carries a poor prognosis, in part because it is difficult to detect early in patients with worsening respiratory symptoms. Pathogenesis of sarcoidosis occurs ... -
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Sperm-borne miRNAs and endo-siRNAs are important for fertilization and preimplantation embryonic development
(2016)Although it is believed that mammalian sperm carry small noncoding RNAs (sncRNAs) into oocytes during fertilization, it remains unknown whether these sperm-borne sncRNAs truly have any function during fertilization and ... -
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Altered Protein Composition and Gene Expression in Strabismic Human Extraocular Muscles and Tendons
(2016)To determine whether structural protein composition and expression of key regulatory genes are altered in strabismic human extraocular muscles. METHODS. Samples from strabismic horizontal extraocular muscles were obtained ... -
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Calcium Sensitization Mechanisms in Gastrointestinal Smooth Muscles
(2016)An increase in intracellular Ca2+ is the primary trigger of contraction of gastrointestinal (GI) smooth muscles. However, increasing the Ca2+ sensitivity of the myofilaments by elevating myosin light chain phosphorylation ...
