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Loss of G Protein gpa-12 Activity Disrupts Axon Growth in C. elegans
Development of the nervous system requires the coordinated action of several
signaling pathway networks. Various signaling pathways, including the highly conserved
Wnt signaling pathway and G protein signaling pathways, regulate processes such as cell
polarity, motility, and axis formation. In some systems, G proteins have been shown to
act in Wnt signaling. However, in C. elegans, it is unknown whether G proteins are
needed for Wnt signaling. Wnt signaling affects several aspects of C. elegans
development, including axon growth and neuronal polarity of the ALM and PLM
neurons. I used the mec-4