Loss of G Protein gpa-12 Activity Disrupts Axon Growth in C. elegans
AuthorLee, Young H.
AdvisorClark, Scott G.
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Development of the nervous system requires the coordinated action of several signaling pathway networks. Various signaling pathways, including the highly conserved Wnt signaling pathway and G protein signaling pathways, regulate processes such as cell polarity, motility, and axis formation. In some systems, G proteins have been shown to act in Wnt signaling. However, in C. elegans, it is unknown whether G proteins are needed for Wnt signaling. Wnt signaling affects several aspects of C. elegans development, including axon growth and neuronal polarity of the ALM and PLM neurons. I used the mec-4