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Multiple Endocrine Neoplasia I : Review of Literature on the Protein Menin and a Case Study
Biochemistry and Molecular Biology
Biochem and Molecular Biology
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A disease characterized by the occurrence of multiple endocrine tumors, Multiple Endocrine Neoplasia type 1, or MEN-1, is found to be the result of mutations in the MEN-1 gene. The MEN-1 gene encodes a protein called menin, which has been puzzling pathologists and cell biologists for years. The intricacy surrounding this protein has led to much effort in research. Recently, menin is shown to regulate many crucial functions in the cell by interacting with other protein factors. These interactions, however, are not well characterized, and the actual functions of menin have not been confirmed. Nevertheless, some recent discoveries and speculations have shed light on the function of menin, suggesting that it is a tumor-suppressor that prevents the onset of the MEN-1 disease. A case study of a 35 year-old Hispanic male diagnosed with MEN-1 is also presented.