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ALM Neuron Migration in C. elegans cle-1; srf-8 mutants
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Neuron migration is an essential process of nervous system development. Neurons must migrate to specific targets in the body for the nervous system to function. The nematode Caenorhabditis elegans is a model organism that shares developmental processes like neuron migration with humans. Anterior lateral microtubule (ALM) neurons migrate a proportionately great distance in C. elegans, and are ideal for studying mutations of the proteins involved in neural migration. cle-1 and srf-8, cause mispositioning of the ALM neurons. cle-1 encodes a type XVIII collagen CLE-1, found concentrated in the nervous system, and srf-8 encodes a p24 protein implicated in the secretory pathway involved in neuron motility. The goal of this study is the generation of a cle-1; srf-8 double-mutant strain to enable the investigation of their combined effect on ALM migration. This would allow for an improved understanding of the molecular mechanisms responsible for neuronal migration.