If you have any problems related to the accessibility of any content (or if you want to request that a specific publication be accessible), please contact us at firstname.lastname@example.org.
ALM Neuron Migration in C. elegans cle-1; srf-8 mutants
AltmetricsView Usage Statistics
Neuron migration is an essential process of nervous system development. Neurons must migrate to specific targets in the body for the nervous system to function. The nematode Caenorhabditis elegans is a model organism that shares developmental processes like neuron migration with humans. Anterior lateral microtubule (ALM) neurons migrate a proportionately great distance in C. elegans, and are ideal for studying mutations of the proteins involved in neural migration. cle-1 and srf-8, cause mispositioning of the ALM neurons. cle-1 encodes a type XVIII collagen CLE-1, found concentrated in the nervous system, and srf-8 encodes a p24 protein implicated in the secretory pathway involved in neuron motility. The goal of this study is the generation of a cle-1; srf-8 double-mutant strain to enable the investigation of their combined effect on ALM migration. This would allow for an improved understanding of the molecular mechanisms responsible for neuronal migration.