Obesity: Regulatory Mechanisms of Feeding Behavior and Energy Homeostasis

Abstract

The mechanisms which regulate feeding behavior and energy balance are evaluated in order to gain new ideas and insight. The importance of this regulatory system within society, which faces the issue of obesity, is discussed. A better understanding of the feeding behavior regulatory system is sought in order to allow for the development of clinical treatments that promote health. Thorough analysis of the literature about the regulatory mechanisms of feeding behavior is performed, to develop new approaches and insight into obesity. The brain/gut communication network, hormone signaling, microbiota, and non-hypothalamus/gut communication systems are evaluated using an integrated approach. This knowledge could have potential value for clinical therapies to resolve the obesity issue. Current knowledge, unanswered questions, and new insight/answers are provided, using figures and text.