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Systemic and Local Cytokine Profile following Spinal Cord Injury in Rats: A Multiplex Analysis

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Author
Mukhamedshina, Yana O.
Akhmetzyanova, Elvira R.
Martynova, Ekaterina V.
Khaiboullina, Svetlana F.
Galieva, Luisa R.
Rizvanov, Albert A.
Date
2017
Type
Article
DOI
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Abstract
Our study of the changes in cytokine profile in blood serum and in the spinal cord after traumatic spinal cord injury (SCI) has shown that an inflammatory reaction and immunological response are not limited to the CNS, but widespread. This fact was confirmed by changes detected in a cytokine profile in blood serum samples [MIP-1 alpha, interleukin 1 (IL-1) alpha, IL-2, IL-5, IL-1 beta, MCP-1, RANTES]. There were also changes in the levels of MIP-1 alpha, IL-1 alpha, IL-2, IL-5, IL-18, GM-colony-stimulating factor, IL-17 alpha, IFN-gamma, IL-10, IL-13, MCP-1, and GRO KC CINC-1 in samples of the rat injured spinal cord. The results underscore the complex cytokine network imbalance exhibited after SCI and show significant changes in the concentrations of 14 cytokines/chemokines with different inflammatory and immunological activities.
Permanent link
http://hdl.handle.net/11714/5154
Subject
acute and subacute periods
cytokine profile
multiplex analysis
rats
spinal cord injury
 
Additional Information
Journal TitleFrontiers in Neurology
RightsCreative Commons Attribution 4.0 International
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Creative Commons Attribution 4.0 International
Except where otherwise noted, this item's license is described as Creative Commons Attribution 4.0 International