Guillain-Barre Syndrome: Identification of Acute Motor Axonal Neuropathy and Representative Case Study

Abstract

Guillain–Barré Syndrome is an autoimmune disease that leaves up to 20 percent of patients severely disabled and approximately five percent dead(Yuki,2012). This is often due to a misdiagnoses which stems from a lack of knowledge about the variants of GBS and their pathology. Molecular mimicry is one possible pathogenic mechanism of auto-immune diseases such as Guillain–Barré(Blank, 2007). Acute Motor Axonal Neuropathy GBS is often linked to C.jejuni infections. This is attributed Anti-GM1 IgG Antibodies Affect on the Nodes of Ranvier which is clearly outlined in a stepwise manner starting from infection and ending with treatment. This is a possible explanation of the link between C.jejuni and AMAN GBS. A case study of a 46 year old patient presenting with GBS-like symptoms is used to demonstrate how to correctly diagnosis AMAN GBS.