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Insights into Clathrin-Independent Endocytotic Pathways of Cholera Toxin
AuthorBogert, Juliana N.
AdvisorBaker, Josh E.
Microbiology and Immunology
Molecular Microbiology and Immunology
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The following literature review aims to provide a comprehensive overview of the pathogenic bacteria Vibrio cholerae and its manifestation as a gastrointestinal disease. Chapter 1 will discuss the pathophysiological method of colonization and infection, diagnostic process, clinical features of the disease, and treatment plans for patients infected with cholera. Additionally, we will discuss environmental factors and epidemiology of the disease, as well as prevention methods and problems going forward in cholera research. Chapter 2 will focus on two experiments that shed light on understanding the mechanisms by which cholera toxin (CT) is endocytosed into host epithelial cells is critical for understanding the pathogenesis of Vibrio cholerae and thus for the development of treatment and prevention against cholera. While clathrin-dependent mechanisms of endocytosis have been well-understood, clathrin-independent mechanisms have been less studied.