Alternative Approaches to Antimicrobial Therapy: Intercepting Quorum Sensing in Pneumococci (Streptococcus pneumoniae)
Sanchez, Lucia 2016 Alternative Approaches to Antimicrobial Therapy - Intercepting Quorum Sensing in Pneumococci.pdf
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Current approaches to antimicrobial therapy are designed to kill bacteria. However, the extensive use of such agents and the pressure they pose has resulted in the widespread emergence of antibiotic-resistant pathogens. Streptococcus pneumoniae is a commensal bacterium that colonizes in the nasopharynx of many humans, but it is also an opportunistic pathogen that can cause infections and results in over a million deaths per year worldwide. S. pneumoniae uses a cell-to-cell communication mechanism called quorum sensing, which enable bacteria to assess their population density, to attack the host. The competence stimulating peptide (CSP) is the 17-amino acid peptide pheromone used to trigger quorum sensing and alteration of its structure can be used attenuate quorum sensing-regulated phenotypes. The evaluation of mono-substituted alanine, D-amino acids, and N-methyl CSP-1 analogs will provide further knowledge regarding the structure-function of CSP-1 and could be used to develop novel quorum sensing modulators as an alternative antimicrobial therapy.