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Now showing items 25-44 of 107

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    De novo formation of an aggregation pheromone precursor by an isoprenyl diphosphate synthase-related terpene synthase in the harlequin bug 

    Lancaster, Jason; Khrimian, Ashot; Young, Sharon; Lehner, Bryan; Luck, Katrin; Wallingford, Anna; Ghosh, Saikat Kumar B.; Zerbe, Philipp; Muchlinski, Andrew; Marek, Paul E.; Sparks, Michael E.; Tokuhisa, James G.; Tittiger, Claus; Koellner, Tobias G.; Weber, Donald C.; Gundersen-Rindal, Dawn E.; Kuhar, Thomas P.; Tholl, Dorothea (2018)
    Insects use a diverse array of specialized terpene metabolites as pheromones in intraspecific interactions. In contrast to plants and microbes, which employ enzymes called terpene synthases (TPSs) to synthesize terpene ...
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    Desiccation tolerance in Anopheles coluzzii: the effects of spiracle size and cuticular hydrocarbons 

    Arcaz, Arthur C.; Huestis, Diana L.; Dao, Adama; Yaro, Alpha S.; Diallo, Moussa; Andersen, John; Blomquist, Gary J.; Lehmann, Tovi (2016)
    The African malaria mosquitoes Anopheles gambiae and Anopheles coluzzii range over forests and arid areas, where they withstand dry spells and months-long dry seasons, suggesting variation in their desiccation tolerance. ...
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    Differences in gene expression between strabismic and normal human extraocular muscles. 

    Altick, Amy L; Feng CY; Schlauch, Karen A; Johnson LA; Von Bartheld, Christopher S (7/3/2012)
    PURPOSE. Strabismic extraocular muscles (EOMs) differ from normal EOMs in structural and functional properties, but the gene expression profile of these two types of EOM has not been examined. Differences in gene expression ...
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    Diffusion of myosin light chain kinase on actin: A mechanism to enhance myosin phosphorylation rates in smooth muscle 

    Hong, Feng; Brizendine, Richard K.; Carter, Michael S.; Alcala, Diego B.; Brown, Avery E.; Chattin, Amy M.; Haldeman, Brian D.; Walsh, Michael P.; Facemyer, Kevin C.; Baker, Josh E.; Cremo, Christine R. (2015)
    Smooth muscle myosin (SMM) light chain kinase (MLCK) phosphorylates SMM, thereby activating the ATPase activity required for muscle contraction. The abundance of active MLCK, which is tightly associated with the contractile ...
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    Divide and Conquer (DC) BLAST: fast and easy BLAST execution within HPC environments 

    Cushman, John C.; Yim, Won Cheol (Peer J, 2017-06-22)
    Bioinformatics is currently faced with very large-scale data sets that lead to computational jobs, especially sequence similarity searches, that can take absurdly long times to run. For example, the National Center for ...
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    Drosophila Spidey/Kar Regulates Oenocyte Growth via PI3-Kinase Signaling 

    Cinnamon, Einat; Makki, Rami; Sawala, Annick; Wickenberg, Leah P.; Blomquist, Gary J.; Tittiger, Claus; Paroush, Ze'ev; Gould, Alex P. (2016)
    Cell growth and proliferation depend upon many different aspects of lipid metabolism. One key signaling pathway that is utilized in many different anabolic contexts involves Phosphatidylinositide 3-kinase (PI3K) and its ...
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    Dynamics of Insulin Signaling in the Black-Legged Tick, Ixodes scapularis 

    Sharma, Arvind; Pooraiiouby, Rana; Guzman, Blanca; Vu, Preston; Gulia-Nuss, Monika; Nuss, Andrew B. (2019)
    Insulin-like peptides (ILPs) have been identified in several invertebrates, particularly insects, and work on these ILPs has revealed many roles including regulation of energy homeostasis, growth, development, and lifespan ...
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    Effect of curcumin on amyloid-like aggregates generated from methionine-oxidized apolipoprotein A-I 

    Krishnamoorthy, Aparna; Tavoosi, Narjes; Chan, Gary K. L.; Liu, Jianfang; Ren, Gang; Cavigiolio, Giorgio; Ryan, Robert O. (2018)
    Curcumin is a polyphenolic phytonutrient that has antineurodegenerative properties. In this study, we investigated the anti-amyloidogenic properties of curcumin. Following incubation with curcumin, intrinsic tryptophan ...
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    Engineering crassulacean acid metabolism to improve water-use efficiency. 

    Borland AM; Hartwell J; Weston DJ; Schlauch, Karen A; Tschaplinski TJ; Tuskan GA; Yang X; Cushman, John C (5/1/2014)
    Climatic extremes threaten agricultural sustainability worldwide. One approach to increase plant water-use efficiency is to introduce crassulacean acid metabolism (CAM) into C3 crops. Such a task requires comprehensive ...
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    EphB2 isolates a human marrow stromal cell subpopulation with enhanced ability to contribute to the resident intestinal cellular pool. 

    Colletti E; El Shabrawy D; Soland M; Yamagami T; Mokhtari S; Osborne, Craig D; Schlauch, Karen A; Zanjani ED; Porada CD; Almeida-Porada G (6/1/2013)
    To identify human bone marrow stromal cell(BMSC) subsets with enhanced ability to engraft/contribute to the resident intestinal cellular pool, we transplanted clonally derived BMSCs into fetalsheep. Analysis at 75 d ...
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    ERCP and laparoscopic cholecystectomy in a combined (one-step) procedure: a random comparison to the standard (two-step) procedure. 

    Jones M; Johnson M; Samourjian E; Schlauch, Karen A; Ozobia N (6/1/2013)
    Background—Current treatment of complicated calculous biliary disease typically involves a two-step procedure consisting of preoperative endoscopic retrograde cholangiopancreatography (ERCP) followed by laparoscopic ...
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    Evolution of Plant P-Type ATPases 

    Pedersen, Christian N. S.; Axelsen, Kristian B.; Harper, Jeffrey F.; Palmgren, Michael G. (2012)
    Five organisms having completely sequenced genomes and belonging to all major branches of green plants (Viridiplantae) were analyzed with respect to their content of P-type ATPases encoding genes. These were the chlorophytes ...
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    Five omic technologies are concordant in differentiating the biochemical characteristics of the berries of five grapevine (Vitis vinifera L.) cultivars 

    Ghan, Ryan; Van Sluyter, Steven C.; Hochberg, Uri; Degu, Asfaw; Hopper, Daniel W.; Tillet, Richard L.; Schlauch, Karen A.; Haynes, Paul A.; Fait, Aaron; Cramer, Grant R. (2015)
    Grape cultivars and wines are distinguishable by their color, flavor and aroma profiles. Omic analyses (transcripts, proteins and metabolites) are powerful tools for assessing biochemical differences in biological systems. ...
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    Five omic technologies are concordant in differentiating the biochemical characteristics of the berries of five grapevine (Vitis vinifera L.) cultivars. 

    Ghan R; Van Sluyter SC; Hochberg U; Degu A; Hopper DW; Tillet RL; Schlauch, Karen A; Haynes PA; Fait A; Cramer, Grant R (11/16/2015)
    Background: Grape cultivars and wines are distinguishable by their color, flavor and aroma profiles. Omic analyses (transcripts, proteins and metabolites) are powerful tools for assessing biochemical differences in biological ...
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    Frax prediction without BMD for assessment of osteoporotic fracture risk. 

    Gadam RK; Schlauch, Karen A; Izuora KE (10/1/2013)
    To compare Fracture Risk Assessment Tool (FRAX) calculations with and without bone mineral density (BMD) in predicting the 10-year probability of hip and major osteoporotic fractures (MOF).
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    Functional genomics of mountain pine beetle (Dendroctonus ponderosae) midguts and fat bodies. 

    Aw T; Schlauch, Karen A; Keeling CI; Young, Sharon L; Bearfield JC; Blomquist GJ; Tittiger, Claus (3/30/2010)
    Background: The mountain pine beetle (Dendroctonus ponderosae) is a significant coniferous forest pest in western North America. It relies on aggregation pheromones to colonize hosts. Its three major pheromone components, ...
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    Gene expression of the liver in response to chronic hypoxia. 

    Baze MM; Schlauch, Karen A; Hayes, Jack P (5/1/2010)
    Hypoxia is an important ecological, evolutionary, and biomedicalstressor. While physiological acclimatization of mammals to hypoxia is wellstudied, the variation in gene expression that underlies acclimatization is not ...
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    Genome-wide association analysis identifies genetic variations in subjects with myalgic encephalomyelitis/chronic fatigue syndrome 

    Schlauch, K. A.; Khaiboullina, S. F.; De Meirleir, K. L.; Rawat, S.; Petereit, J.; Rizvanov, A. A.; Blatt, N.; Mijatovic, T.; Kulick, D.; Palotas, A.; Lombardi, V. C. (2016)
    Myalgic encephalomyelitis, also known as chronic fatigue syndrome or ME/CFS, is a multifactorial and debilitating disease that has an impact on over 4 million people in the United States alone. The pathogenesis of ME/CFS ...
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    Genomic insights into the Ixodes scapularis tick vector of Lyme disease 

    Gulia-Nuss, Monika; Nuss, Andrew B.; Meyer, Jason M.; Sonenshine, Daniel E.; Roe, R. Michael; Waterhouse, Robert M.; Sattelle, David B.; de la Fuente, Jose; Ribeiro, Jose M.; Megy, Karine; Thimmapuram, Jyothi; Miller, Jason R.; Walenz, Brian P.; Koren, Sergey; Hostetler, Jessica B.; Thiagarajan, Mathangi; Joardar, Vinita S.; Hannick, Linda I.; Bidwell, Shelby; Hammond, Martin P.; Young, Sarah; Zeng, Qiandong; Abrudan, Jenica L.; Almeida, Francisca C.; Ayllon, Nieves; Bhide, Ketaki; Bissinger, Brooke W.; Bonzon-Kulichenko, Elena; Buckingham, Steven D.; Caffrey, Daniel R.; Caimano, Melissa J.; Croset, Vincent; Driscoll, Timothy; Gilbert, Don; Gillespie, Joseph J.; Giraldo-Calderon, Gloria I.; Grabowski, Jeffrey M.; Jiang, David; Khalil, Sayed M. S.; Kim, Donghun; Kocan, Katherine M.; Koci, Juraj; Kuhn, Richard J.; Kurtti, Timothy J.; Lees, Kristin; Lang, Emma G.; Kennedy, Ryan C.; Kwon, Hyeogsun; Perera, Rushika; Qi, Yumin; Radolf, Justin D.; Sakamoto, Joyce M.; Sanchez-Gracia, Alejandro; Severo, Maiara S.; Silverman, Neal; Simo, Ladislav; Tojo, Marta; Tornador, Cristian; Van Zee, Janice P.; Vazquez, Jesus; Vieira, Filipe G.; Villar, Margarita; Wespiser, Adam R.; Yang, Yunlong; Zhu, Jiwei; Arensburger, Peter; Pietrantonio, Patricia V.; Barker, Stephen C.; Shao, Renfu; Zdobnov, Evgeny M.; Hauser, Frank; Grimmelikhuijzen, Cornelis J. P.; Park, Yoonseong; Rozas, Julio; Benton, Richard; Pedra, Joao H. F.; Nelson, David R.; Unger, Maria F.; Tubio, Jose M. C.; Tu, Zhijian; Robertson, Hugh M.; Shumway, Martin; Sutton, Granger; Wortman, Jennifer R.; Lawson, Daniel; Wikel, Stephen K.; Nene, Vishvanath M.; Fraser, Claire M.; Collins, Frank H.; Birren, Bruce; Nelson, Karen E.; Caler, Elisabet; Hill, Catherine A. (2016)
    Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic ...
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    Glut4 Is Sorted from a Rab10 GTPase-independent Constitutive Recycling Pathway into a Highly Insulinresponsive Rab10 GTPase-dependent Sequestration Pathway after Adipocyte Differentiation 

    Brewer, Paul Duffield; Habtemichael, Estifanos N.; Romenskaia, Irina; Mastick, Cynthia Corley; Coster, Adelle C. F. (2016)
    The RabGAP AS160/TBC1D4 controls exocytosis of the insulin-sensitive glucose transporter Glut4 in adipocytes. Glut4 is internalized and recycled through a highly regulated secretory pathway in these cells. Glut4 also cycles ...