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Now showing items 1-20 of 111

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    Cytosolic ascorbate peroxidase 1 is a central component of the reactive oxygen gene network of Arabidopsis. 

    Davletova, Sholpan; Rizhsky, Ludmila; Liang, Hongjian; Shengqiang, Zong; Oliver, David J.; Coutu, Jesse; Shulaev, Vladimir; Schlauch, Karen A.; Mittler, Ron (1/1/2005)
    Reactive oxygen species (ROS), such as O2 and H2O2, play a key role in plant metabolism, cellular signaling, and defense. In leaf cells, the chloroplast is considered to be a focal point of ROS metabolism. It is a major ...
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    The Vitis vinifera C-repeat binding protein 4 (VvCBF4) transcriptional factor enhances freezing tolerance in wine grape. 

    Tillett, Richard L.; Wheatley, M.D.; Tattersall, E.A.; Schlauch, Karen A.; Cramer, Grant R.; Cushman, John C. (1/1/2012)
    Chilling and freezing can reduce significantly vine survival and fruit set in Vitis vinifera wine grape. To overcome such production losses, a recently identified grapevine C-repeat binding factor (CBF) gene, VvCBF4, was ...
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    Inhibition of Aβ42 oligomerization in yeast by a PICALM ortholog and certain FDA approved drugs 

    Park, Sei-Kyoung; Ratia, Kiira; Ba, Mariam A.; Liebman; Maria Valencik; Liebman, Susan W. (1/20/2016)
    The formation of small Aβ42 oligomers has been implicated as a toxic species in Alzheimer disease (AD). In strong support of this hypothesis we found that overexpression of Yap1802, the yeast ortholog of the human AD risk ...
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    The zinc-finger protein Zat12 plays a central role in reactive oxygen and abiotic stress signaling in Arabidopsis. 

    Davletova, Sholpan; Schlauch, Karen A.; Coutu, Jesse; Mittler, Ron (10/1/2005)
    Plant acclimation to environmental stress is controlled by a complex network of regulatory genes that compose distinct stressresponse regulons. In contrast to many signaling and regulatory genes that are stress specific, ...
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    Frax prediction without BMD for assessment of osteoporotic fracture risk. 

    Gadam, Ramesh; Schlauch, Karen A.; Izuora, Kenneth (10/1/2013)
    To compare Fracture Risk Assessment Tool (FRAX) calculations with and without bone mineral density (BMD) in predicting the 10-year probability of hip and major osteoporotic fractures (MOF).
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    The human uterine smooth muscle S-nitrosoproteome fingerprint in pregnancy, labor, and preterm labor. 

    Ulrich C.; Quilici, David R.; Schlauch, Karen A.; Buxton, Iain L. O. (10/15/2013)
    Molecular mechanisms involved in uterine quiescence during gestation and those responsible for induction of labor at term are incompletely known. More than 10% of babies born worldwide are premature and 1,000,000 die ...
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    Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients: a pilot study. 

    Wu Y; Yoder A; Yu D; Wang W; Liu J; Barrett T; Wheeler D; Schlauch, Karen A (10/17/2008)
    Cofilin is an actin-depolymerizing factor that regulates actin dynamics critical for T cell migration and T cell activation. In unstimulated resting CD4 T cells, cofilin exists largely as a phosphorylated inactive form. ...
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    Transcriptional and apoptotic responses of THP-1 cells to challenge with toxigenic, and non-toxigenic Bacillus anthracis. 

    Bradburne, Christopher; Chung, Myung-Chul; Zong, Qin; Schlauch, Karen A.; Liu, Derong; Popova, Taissia; Popova, Anna; Bailey, Charles; Soppet, Dan; Popov, Serguei (11/13/2008)
    Background: Bacillus anthracis secretes several virulence factors targeting different host organs and cell types during inhalational anthrax infection. The bacterial expression of a key virulence factor, lethal toxin (LeTx) ...
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    Transcriptomic and metabolite analyses of Cabernet Sauvignon grape berry development. 

    Deluc, Laurent G.; Grimplet, Jerome; Wheatley, M.D.; Tillett, Richard L.; Quilici, David R.; Osborne, Craig D.; Schooley, David A.; Schlauch, Karen A.; Cushman, John C.; Cramer, Grant R. (11/22/2007)
    Background: Grape berry development is a dynamic process that involves a complex series of molecular genetic and biochemical changes divided into three major phases. During initial berry growth (Phase I), berry size increases ...
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    Transcriptomic analysis of the late stages of grapevine (Vitis vinifera cv. Cabernet Sauvignon) berry ripening reveals significant induction of ethylene signaling and flavor pathways in the skin. 

    Cramer, Grant R.; Ghan, Ryan M.; Schlauch, Karen A.; Tillett, Richard L.; Heymann, H.; Ferrarini, A.; Delledonne, M.; Zenoni, S.; Fasoli, M.; Pezzotti, M. (12/14/2014)
    Background: Grapevine berry, a nonclimacteric fruit, has three developmental stages; the last one is when berry color and sugar increase. Flavors derived from terpenoid and fatty acid metabolism develop at the very end of ...
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    Previously Unidentified Single Nucleotide Polymorphisms in HIV/AIDS Cases Associate with Clinical Parameters and Disease Progression 

    Anokhin, Vladimir V.; Bakhteeva, Liliia B.; Khasanova, Gulshat R.; Khaiboullina, Svetlana F.; Martynova, Ekaterina V.; Tillett, Richard L.; Schlauch, Karen A.; Lombardi, Vincent C.; Rizvanov, Albert A. (12/5/2016)
    The genetic background of an individual plays an important role in the progression of HIV infection to AIDS. Identifying previously unknown or uncharacterized single nucleotide polymorphisms (SNPs) that associate with ...
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    Chemical Mimicry as an Integrating Mechanism for Three Termitophiles Associated With Reticulitermes Virginicus (Banks) 

    Howard, Ralph W.; McDaniel, C. A.; Blomquist, Gary J. (1982)
    The mechanisms by which termitophiles integrate themselves into the social life of termite colonies have long intrigued entomologists (Kistner, 1979). Various authors have suggested that plausible integration mechanisms ...
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    Calcium-Dependent Protein Kinases from Arabidopsis Show Substrate Specificity Differences in an Analysis of 103 Substrates 

    Curran, Amy; Chang, Ing-Feng; Chang, Chia-Lun; Garg, Shilpi; Miguel, Rodriguez M.; Barron, Yoshimi D.; Li, Ying; Romanowsky, Shawn; Cushman, John C.; Gribskov, Michael; Harmon, Alice; Harper, Jeffrey F. (2011)
    The identification of substrates represents a critical challenge for understanding any protein kinase-based signal transduction pathway. In Arabidopsis, there are more than 1000 different protein kinases, 34 of which belong ...
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    Evolution of Plant P-Type ATPases 

    Pedersen, Christian N. S.; Axelsen, Kristian B.; Harper, Jeffrey F.; Palmgren, Michael G. (2012)
    Five organisms having completely sequenced genomes and belonging to all major branches of green plants (Viridiplantae) were analyzed with respect to their content of P-type ATPases encoding genes. These were the chlorophytes ...
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    Multiplex analysis of serum cytokines in humans with hantavirus pulmonary syndrome 

    Morzunov, Sergey P.; Khaiboullina, Svetlana F.; St Jeor, Stephen; Rizvanov, Albert A.; Lombardi, Vincent C. (Frontiers in Immunology, 2015)
    Hantavirus pulmonary syndrome (HPS) is an acute zoonotic disease transmitted primarily through inhalation of virus-contaminated aerosols. Hantavirus infection of endothelial cells leads to increased vascular permeability ...
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    Loss of the Arabidopsis thaliana P4-ATPases ALA6 and ALA7 impairs pollen fitness and alters the pollen tube plasma membrane 

    McDowell, Stephen C.; López-Marqués, Rosa L.; Cohen, Taylor; Brown, Elizabeth; Rosenberg, Alexa; Palmgren, Michael G.; Harper, Jeffrey F. (2015)
    Members of the P4 subfamily of P-type ATPases are thought to create and maintain lipid asymmetry in biological membranes by flipping specific lipids between membrane leaflets. In Arabidopsis, 7 of the 12 Aminophospholipid ...
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    The pineapple genome and the evolution of CAM photosynthesis 

    Ming, Ray; VanBuren, Robert; Wai, Ching Man; Tang, Haibao; Schatz, Michael C.; Bowers, John E.; Lyons, Eric; Wang, Ming-Li; Chen, Jung; Biggers, Eric; Zhang, Jisen; Huang, Lixian; Zhang, Lingmao; Miao, Wenjing; Zhang, Jian; Ye, Zhangyao; Miao, Chenyong; Lin, Zhicong; Wang, Hao; Zhou, Hongye; Yim, Won C.; Priest, Henry D.; Zheng, Chunfang; Woodhouse, Margaret; Edger, Patrick P.; Guyot, Romain; Guo, Hao-Bo; Guo, Hong; Zheng, Guangyong; Singh, Ratnesh; Sharma, Anupma; Min, Xiangjia; Zheng, Yun; Lee, Hayan; Gurtowski, James; Sedlazeck, Fritz J.; Harkess, Alex; McKain, Michael R.; Liao, Zhenyang; Fang, Jingping; Liu, Juan; Zhang, Xiaodan; Zhang, Qing; Hu, Weichang; Qin, Yuan; Wang, Kai; Chen, Li-Yu; Shirley, Neil; Lin, Yann-Rong; Liu, Li-Yu; Hernandez, Alvaro G.; Wright, Chris L.; Bulone, Vincent; Tuskan, Gerald A.; Heath, Katy; Zee, Francis; Moore, Paul H.; Sunkar, Ramanjulu; Leebens-Mack, James H.; Mockler, Todd; Bennetzen, Jeffrey L.; Freeling, Michael; Sankoff, David; Paterson, Andrew H.; Zhu, Xinguang; Yang, Xiaohan; Smith, J. Andrew C.; Cushman, John C.; Paull, Robert E.; Yu, Qingyi (2015)
    Pineapple (Ananas comosus (L.) Merr.) is the most economically valuable crop possessing crassulacean acid metabolism (CAM), a photosynthetic carbon assimilation pathway with high water-use efficiency, and the second most ...
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    2-Fluoro-L-Fucose Is a Metabolically Incorporated Inhibitor of Plant Cell Wall Polysaccharide Fucosylation 

    Villalobos, Jose A.; Yi, Bo R.; Wallace, Ian S. (2015)
    The monosaccharide L-fucose (L-Fuc) is a common component of plant cell wall polysaccharides and other plant glycans, including the hemicellulose xyloglucan, pectic rhamnogalacturonan-I (RG-I) and rhamnogalacturonan-II ...
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    Diffusion of myosin light chain kinase on actin: A mechanism to enhance myosin phosphorylation rates in smooth muscle 

    Hong, Feng; Brizendine, Richard K.; Carter, Michael S.; Alcala, Diego B.; Brown, Avery E.; Chattin, Amy M.; Haldeman, Brian D.; Walsh, Michael P.; Facemyer, Kevin C.; Baker, Josh E.; Cremo, Christine R. (2015)
    Smooth muscle myosin (SMM) light chain kinase (MLCK) phosphorylates SMM, thereby activating the ATPase activity required for muscle contraction. The abundance of active MLCK, which is tightly associated with the contractile ...
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    Gut-associated plasmacytoid dendritic cells display an immature phenotype and upregulated granzyme B in subjects with HIV/AIDS 

    Boichuk, Sergei V.; Khaiboullina, Svetlana F.; Ramazanov, Bulat R.; Khasanova, Gulshat R.; Ivanovskaya, Karina A.; Nizamutdinov, Evgeny Z.; Sharafutdinov, Marat R.; Martynova, Ekaterina V.; DeMeirleir, Kenny L.; Hulstaert, Jan; Anokhin, Vladimir A.; Rizvanov, Albert A.; Lombardi, Vincent C. (2015)
    Plasmacytoid dendritic cells (pDCs) in the periphery of subjects with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) decrease over time, and the fate of these cells has been the subject of ...