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The mission of the Department of Biochemistry and Molecular Biology is to provide strong educational programs for undergraduate, graduate, and professional students, to conduct high quality research in biochemistry, molecular biology and biotechnology, and to effectively transmit scientific knowledge to the general public.

Theses and Dissertations for Biochemistry and Molecular Biology

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    A Thermophilic Phage Endolysin Fusion to a Clostridium perfringens-Specific Cell Wall Binding Domain Creates an Anti-Clostridium Antimicrobial with Improved Thermostability 

    Swift, Steven M.; Seal, Bruce S.; Garrish, Johnna K.; Oakley, Brian B.; Hiett, Kelli; Yeh, Hung-Yueh; Woolsey, Rebekah; Schegg, Kathleen M.; Line, John Eric; Donovan, David M. (2015)
    Clostridium perfringens is the third leading cause of human foodborne bacterial disease and is the presumptive etiologic agent of necrotic enteritis among chickens. Treatment of poultry with antibiotics is becoming less ...
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    Subfunctionalization of cation/proton antiporter 1 genes in grapevine in response to salt stress in different organs 

    Ma, Yuanchun; Wang, Jiaoyang; Zhong, Yan; Geng, Fang; Cramer, Grant R.; Cheng, Zong-Ming (2015)
    Cation/proton antiporter 1 (CPA1) proteins function as regulators of monovalent ions, pH homeostasis, and other developmental processes in plants. Better understanding of the expression and regulation of CPA1 in plant ...
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    Five omic technologies are concordant in differentiating the biochemical characteristics of the berries of five grapevine (Vitis vinifera L.) cultivars 

    Ghan, Ryan; Van Sluyter, Steven C.; Hochberg, Uri; Degu, Asfaw; Hopper, Daniel W.; Tillet, Richard L.; Schlauch, Karen A.; Haynes, Paul A.; Fait, Aaron; Cramer, Grant R. (2015)
    Grape cultivars and wines are distinguishable by their color, flavor and aroma profiles. Omic analyses (transcripts, proteins and metabolites) are powerful tools for assessing biochemical differences in biological systems. ...
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    Short day transcriptomic programming during induction of dormancy in grapevine 

    Fennell, Anne Y.; Schlauch, Karen A.; Gouthu, Satyanarayana; Deluc, Laurent G.; Khadka, Vedbar; Sreekantan, Lekha; Grimplet, Jerome; Cramer, Grant R.; Mathiason, Katherine L. (2015)
    Bud dormancy in grapevine is an adaptive strategy for the survival of drought, high and low temperatures and freeze dehydration stress that limit the range of cultivar adaptation. Therefore, development of a comprehensive ...
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    The pineapple genome and the evolution of CAM photosynthesis 

    Ming, Ray; VanBuren, Robert; Wai, Ching Man; Tang, Haibao; Schatz, Michael C.; Bowers, John E.; Lyons, Eric; Wang, Ming-Li; Chen, Jung; Biggers, Eric; Zhang, Jisen; Huang, Lixian; Zhang, Lingmao; Miao, Wenjing; Zhang, Jian; Ye, Zhangyao; Miao, Chenyong; Lin, Zhicong; Wang, Hao; Zhou, Hongye; Yim, Won C.; Priest, Henry D.; Zheng, Chunfang; Woodhouse, Margaret; Edger, Patrick P.; Guyot, Romain; Guo, Hao-Bo; Guo, Hong; Zheng, Guangyong; Singh, Ratnesh; Sharma, Anupma; Min, Xiangjia; Zheng, Yun; Lee, Hayan; Gurtowski, James; Sedlazeck, Fritz J.; Harkess, Alex; McKain, Michael R.; Liao, Zhenyang; Fang, Jingping; Liu, Juan; Zhang, Xiaodan; Zhang, Qing; Hu, Weichang; Qin, Yuan; Wang, Kai; Chen, Li-Yu; Shirley, Neil; Lin, Yann-Rong; Liu, Li-Yu; Hernandez, Alvaro G.; Wright, Chris L.; Bulone, Vincent; Tuskan, Gerald A.; Heath, Katy; Zee, Francis; Moore, Paul H.; Sunkar, Ramanjulu; Leebens-Mack, James H.; Mockler, Todd; Bennetzen, Jeffrey L.; Freeling, Michael; Sankoff, David; Paterson, Andrew H.; Zhu, Xinguang; Yang, Xiaohan; Smith, J. Andrew C.; Cushman, John C.; Paull, Robert E.; Yu, Qingyi (2015)
    Pineapple (Ananas comosus (L.) Merr.) is the most economically valuable crop possessing crassulacean acid metabolism (CAM), a photosynthetic carbon assimilation pathway with high water-use efficiency, and the second most ...
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    Diffusion of myosin light chain kinase on actin: A mechanism to enhance myosin phosphorylation rates in smooth muscle 

    Hong, Feng; Brizendine, Richard K.; Carter, Michael S.; Alcala, Diego B.; Brown, Avery E.; Chattin, Amy M.; Haldeman, Brian D.; Walsh, Michael P.; Facemyer, Kevin C.; Baker, Josh E.; Cremo, Christine R. (2015)
    Smooth muscle myosin (SMM) light chain kinase (MLCK) phosphorylates SMM, thereby activating the ATPase activity required for muscle contraction. The abundance of active MLCK, which is tightly associated with the contractile ...
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    Gut-associated plasmacytoid dendritic cells display an immature phenotype and upregulated granzyme B in subjects with HIV/AIDS 

    Boichuk, Sergei V.; Khaiboullina, Svetlana F.; Ramazanov, Bulat R.; Khasanova, Gulshat R.; Ivanovskaya, Karina A.; Nizamutdinov, Evgeny Z.; Sharafutdinov, Marat R.; Martynova, Ekaterina V.; DeMeirleir, Kenny L.; Hulstaert, Jan; Anokhin, Vladimir A.; Rizvanov, Albert A.; Lombardi, Vincent C. (2015)
    Plasmacytoid dendritic cells (pDCs) in the periphery of subjects with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) decrease over time, and the fate of these cells has been the subject of ...
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    2-Fluoro-L-Fucose Is a Metabolically Incorporated Inhibitor of Plant Cell Wall Polysaccharide Fucosylation 

    Villalobos, Jose A.; Yi, Bo R.; Wallace, Ian S. (2015)
    The monosaccharide L-fucose (L-Fuc) is a common component of plant cell wall polysaccharides and other plant glycans, including the hemicellulose xyloglucan, pectic rhamnogalacturonan-I (RG-I) and rhamnogalacturonan-II ...
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    Inter-laboratory optimization of protein extraction method for the assessment of rice endogenous allergens 

    Satoh, Rie, Teshima, R.; Nakamura, R.; Kitta, K.; Satoh, R.; Lang, G.-H.; Schegg, K.; Blumenthal, K.; Hicks, L.; Rouquie, D.; Herman, R. A.; Guicheney, Herouet C.; Ladics, G.; McClain, S.; Poulsen, L. K.; Ward, J. M.; Doerrer, N.; Bars, R.; Corney, S.; Rascle, J.-B. (2015)
    In rice, several allergens have been identified such as the non-specific lipid transfer protein-1, the ?-amylase/trypsin-inhibitors, the ?-globulin, the 33 kDa glyoxalase I (Gly I), the 52–63 kDa globulin, and the granule-bound ...
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    Multiplex analysis of serum cytokines in humans with hantavirus pulmonary syndrome 

    Morzunov, Sergey P.; Khaiboullina, Svetlana F.; St Jeor, Stephen; Rizvanov, Albert A.; Lombardi, Vincent C. (Frontiers in Immunology, 2015)
    Hantavirus pulmonary syndrome (HPS) is an acute zoonotic disease transmitted primarily through inhalation of virus-contaminated aerosols. Hantavirus infection of endothelial cells leads to increased vascular permeability ...
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    GWAS and PheWAS of red blood cell components in a Northern Nevadan cohort 

    Read, Robert W.; Schlauch, Karen A.; Elhanan, Gai; Metcalf, William J.; Slonim, Anthony D.; Aweti, Ramsey; Borkowski, Robert; Grzymski, Joseph J. (PLoS ONE, 2019)
    In this study, we perform a full genome-wide association study (GWAS) to identify statistically significantly associated single nucleotide polymorphisms (SNPs) with three red blood cell (RBC) components and follow it with ...
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    The Crosstalk between Acetylation and Phosphorylation: Emerging New Roles for HDAC Inhibitors in the Heart 

    Habibian, Justine; Ferguson, Bradley S. (International Journal of Molecular Sciences, 2019)
    Approximately five million United States (U.S.) adults are diagnosed with heart failure (HF), with eight million U.S. adults projected to suffer from HF by 2030. With five-year mortality rates following HF diagnosis ...
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    Humoral Immunity Profiling of Subjects with Myalgic Encephalomyelitis Using a Random Peptide Microarray Differentiates Cases from Controls with High Specificity and Sensitivity 

    Singh, Sahajpreet; Stafford, Phillip; Schlauch, Karen A.; Tillett, Richard R.; Gollery, Martin; Johnston, Stephen Albert; Khaiboullina, Svetlana F.; De Meirleir, Kenny L.; Rawat, Shanti; Mijatovic, Tatjana; Subramanian, Krishnamurthy; Palotas, Andras; Lombardi, Vincent C. (2018)
    Myalgic encephalomyelitis (ME) is a complex, heterogeneous illness of unknown etiology. The search for biomarkers that can delineate cases from controls is one of the most active areas of ME research
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    Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis 

    Park, Sei-Kyoung; Hong, Joo Y.; Arslan, Fatih; Kanneganti, Vydehi; Patel, Basant; Tietsort, Alex; Tank, Elizabeth M. H.; Li, Xingli; Barmada, Sami J.; Liebman, Susan W. (2017)
    Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by selective loss of motor neurons with inclusions frequently containing the RNA/DNA binding protein TDP-43. Using a yeast model ...
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    The common transcriptional subnetworks of the grape berry skin in the late stages of ripening 

    Ghan, Ryan; Petereit, Juli; Tillett, Richard L.; Schlauch, Karen A.; Toubiana, David; Fait, Aaron; Cramer, Grant R. (2017)
    Wine grapes are important economically in many countries around the world. Defining the optimum time for grape harvest is a major challenge to the grower and winemaker. Berry skins are an important source of flavor, color ...
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    The Kalanchoe genome provides insights into convergent evolution and building blocks of crassulacean acid metabolism 

    Yang, Xiaohan; Hu, Rongbin; Yin, Hengfu; Jenkins, Jerry; Shu, Shengqiang; Tang, Haibao; Liu, Degao; Weighill, Deborah A.; Yim, Won Cheol; Ha, Jungmin; Heyduk, Karolina; Goodstein, David M.; Guo, Hao-Bo; Moseley, Robert C.; Fitzek, Elisabeth; Jawdy, Sara; Zhang, Zhihao; Xie, Meng; Hartwell, James; Grimwood, Jane; Abraham, Paul E.; Mewalal, Ritesh; Beltran, Juan D.; Boxall, Susanna F.; Dever, Louisa V.; Palla, Kaitlin J.; Albion, Rebecca; Garcia, Travis; Mayer, Jesse A.; Lim, Sung Don; Wai, Ching Man; Peluso, Paul; Van Buren, Robert; De Paoli, Henrique Cestari; Borland, Anne M.; Guo, Hong; Chen, Jin-Gui; Muchero, Wellington; Yin, Yanbin; Jacobson, Daniel A.; Tschaplinski, Timothy J.; Hettich, Robert L.; Ming, Ray; Winter, Klaus; Leebens-Mack, James H.; Smith, J. Andrew C.; Cushman, John C.; Schmutz, Jeremy; Tuskan, Gerald A. (2017)
    Crassulacean acid metabolism (CAM) is a water-use efficient adaptation of photosynthesis that has evolved independently many times in diverse lineages of flowering plants. We hypothesize that convergent evolution of protein ...
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    An rbcL mRNA-binding protein is associated with C-3 to C-4 evolution and light-induced production of Rubisco in Flaveria 

    Yerramsetty, Pradeep; Agar, Erin M.; Yim, Won C.; Cushman, John C.; Berry, James O. (2017)
    Nuclear-encoded RLSB protein binds chloroplastic rbcL mRNA encoding the Rubisco large subunit. RLSB is highly conserved across all groups of land plants and is associated with positive post-transcriptional regulation of ...
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    Comparative transcriptomics of mountain pine beetle pheromone-biosynthetic tissues and functional analysis of CYP6DE3 

    Nadeau, J. A.; Petereit, J.; Tillett, R. L.; Jung, K.; Fotoohi, M.; MacLean, M.; Young, S.; Schlauch, K.; Blomquist, G. J.; Tittiger, C. (2017)
    The mountain pine beetle (MPB, Dendroctonus ponderosae Hopkins) is a highly destructive pest of pine forests in western North America. During flight to a new host tree and initiation of feeding, mountain pine beetles release ...
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    Occurrence and Biosynthesis of Alkyl Hydroxycinnamates in Plant Lipid Barriers 

    Domergue, Frederic; Kosma, Dylan K. (2017)
    The plant lipid barriers cuticle and suberin represent one of the largest biological interfaces on the planet. They are comprised of an insoluble polymeric domain with associated organic solvent-soluble waxes. Suberin-associated ...
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    BRASSINOSTEROID INSENSITIVE2 negatively regulates cellulose synthesis in Arabidopsis by phosphorylating cellulose synthase 1 

    Sanchez-Rodriguez, Clara; Ketelaar, KassaDee; Schneider, Rene; Villalobos, Jose A.; Somerville, Chris R.; Persson, Staffan; Wallace, Ian S. (2017)
    The deposition of cellulose is a defining aspect of plant growth and development, but regulation of this process is poorly understood. Here, we demonstrate that the protein kinase BRASSINOSTEROID INSENSITIVE2 (BIN2), a key ...

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