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Gata4 is required for Testicular Development
Sex differentiation occurs at embryonic day 10.5 (E10.5) in the mouse. In the XY mouse embryos, appearance of testis cords at E11.5 marks the onset of testis formation. The primary testis cords subsequently undergo further ...
A Tale of RNA Circles: Function of Circular RNAs in Reproduction
CircRNAs are a group of RNA circles harboring exons out of order from their normal genomic contexts. Although discovered ~20 years ago, circRNAs have since then been overlooked because they were regarded as “transcriptional ...
Expression and function of small non-coding RNAs in the mouse testis
Spermatogenesis is complex and fascinating process of differentiation. It starts with the renewal of the rare spermatogonial stem cells, followed by the proliferation of differentiated spermatogonia. The latter cells form ...
Characterization of the Genes Essential for Mouse Spermatogenesis
Spermatogenesis is a complex process that starts with the proliferation of differentiated spermatogonia through mitotic division. Primary spermatocytes produced from differentiated spermatogonia enter the prolonged prophase ...
The Regulators of Mouse Spermatogenic Cell Fate Decisions
Spermatogenesis is the process of maturation of a male germ cell from a spermatogonium to a spermatozoon. During this developmental process, spermatogonia, on one hand, replicate themselves as a replacement of germ cell ...
Identification and Characterization of Novel Somatic and Germ Cell Small RNA Species
Small non-protein-coding RNAs are essential, ubiquitous molecules found in every cell. Their functions range from post-transcriptional regulation of mRNA expression to epigenetic control of the genome. Small noncoding ...
Physiological roles of sperm-borne small RNAs
The discovery of RNA interference (RNAi) nearly two decades ago revealed a complex and ubiquitous layer of gene expression regulation in both plants and animals. Small noncoding RNAs (sncRNAs), the effectors of RNAi, are ...
Epigenetic regulation of spermatogenesis and transgenerational epigenetic inheritance
Epigenetics is defined as genomic modifications that alter gene expression without changing the nucleic acid sequence. These modifications come in hundreds of forms and affect both DNA and RNA. Recently, the field of ...