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Axon guidance, behavior and learning: The quest from Netrin to the brain
Axon guidance is fundamental to the initial organization of the brain, and as a result, the organization of behavior and learning in the mature animal. The impressive plasticity inherent in complex nervous systems allows ...
Genetic Dissection Of Axon Guidance Mechanisms In the Drosophila Nerve Cord
Axon guidance is the process by which the neurons in a developing organism extend their axons and make the connections that will carry vital information and commands throughout the brain and body. The interactions of the ...
Genetic Analysis of Drosophila Stomatogastric Nervous System
The enteric nervous system (ENS) is of critical importance to an organism, as it controls the function of the gastrointestinal system. The ENS is remarkably complex, and although sculpted early in development, has to ...
Drosophila RET Mutants as a Model for Hirschsprung’s Disease
Mutant RET protein can fail to activate neural migration pathways causing the newborn colon to lack neurons for peristalsis. Considered as Hirschsprung’s disease, no treatment exists to induce proper migration thus requiring ...
Dscam Switches Slit Repulsion To Mild Attraction Via Robo Receptors
Axon guidance is a critical part of neural development, the process thatgenerates and shapes the nervous system, from the earliest stages ofembryogenesis to the last years of life. Axons navigate to reach their correcttargets ...
Origins of Ret Signaling in Development of the Insect Gut Nervous System: A Model for Enteric Nervous System Development
Understanding the evolutionary origins of neurotrophic signaling guiding the formation and upkeep of the central and peripheral nervous systems (CNS/PNS), can offer insights into the basis of development and congenital ...