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Modulation of Kaposi's Sarcoma-associated Herpesvirus (KSHV/HHV8) origin-dependent DNA replication by K-bZIP, K-Rta, and LANA
There are eight Kaposi Sarcoma-associated Herpesvirus (KSHV) viral-encoded proteins that are necessary for lytic origin-dependent DNA replication. Six of the eight proteins have a high level of homology to other herpesvirus ...
The Role of ORF59 in Coupling Viral Transcription and Replication
KSHV (Kaposi’s sarcoma-associated herpesvirus) can cause multiple malignancies including Kaposi’s Sarcoma, Primary Effusion Lymphoma, and Multicentric Castleman’s Disease in immunocompromised individuals. KSHV, like other ...
KSHV encoded viral processivity factor, ORF59, regulates multiple pathways for viral replication
Kaposi’s Sarcoma-Associated Herpesvirus (KSHV), or human herpesvirus 8 (HHV-8), is a tumorigenic herpesvirus tightly linked with various human malignancies including Kaposi’s Sarcoma, Primary Effusion Lymphomas (PELs), and ...
Determination of KSHV lytic DNA replication origin using SMARD and its control mechanism
While it is clear that Kaposi's Sarcoma-associated Herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma (KS) lesions and non-Hodgkins lymphomas such as primary effusion lymphoma (PEL) and multicentric Castleman's ...
Dynamics of KSHV gene expression during de novo infection and the role of LANA in immune modulation
Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic human herpes virus that has been linked to the development of multiple malignancies including Kaposi's sarcoma, primary effusion lymphoma, and multicentric ...