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Docosahexaenoic Acid Attenuates Bioenergetic Function and Inhibits Mammary Carcinoma Survival and Progression
Breast cancer is the second leading cause of cancer-related mortality for women in the United States. Only 5-10 percent of diagnosed breast cancer cases are attributed to known hereditary factors, making breast cancer ...
Characterization of CD8 T cell responses after immunotherapy: The role of antigen specificity in anti-tumor effects
We have previously demonstrated that immunotherapy with an agonist CD40 antibody in combination with IL-2 results in synergistic CD4-indenpendent anti-tumor effects but actually impairs the ability to generate an ...
Cancer Immunotherapy: Limitations and Potential Strategies
Cancer immunotherapy is a treatment strategy which uses a patient's own immune system to induce or enhance immune responses against cancer. Although immunotherapy has been used for the treatment of a variety of cancers ...
KSHV encoded viral processivity factor, ORF59, regulates multiple pathways for viral replication
Kaposi’s Sarcoma-Associated Herpesvirus (KSHV), or human herpesvirus 8 (HHV-8), is a tumorigenic herpesvirus tightly linked with various human malignancies including Kaposi’s Sarcoma, Primary Effusion Lymphomas (PELs), and ...