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Defects in protein trafficking affect expression of GPCRs in C. elegans
In the nematode C. elegans, the bilaterally symmetric PVQ neurons are located in the tail and each extends an axon along the ventral nerve cord to the head. Several G protein coupled receptors (EGL-47, SRA-6) are terminally ...
Regulation of Axon length by RPM-1 via the DLK-1 Signaling pathway
The formation of neuronal connections is a complex process that involves several key steps: initiation of the axon and growth cone, axon extension, target recognition, axon growth termination and formation of synapses. ...
Wnt signaling controls anteroposterior polarity in C. elegans mechanosensory neurons
The Wnt family of secreted proteins is responsible for a multitude of developmental processes, often functioning as a morphogen during early development. Here, we address the impact of Wnt signaling on the anteroposterior ...
Regulation of Neuronal Polarity by Wnt Signaling
Wnts are highly conserved secreted glycoproteins that function in many developmental processes. Cell surface receptors, including the Frizzleds (Fz), ROR, and RYK families of proteins, bind Wnts to activate a number of ...