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Comprehensive Analysis of LANA Interacting Proteins Essential for Viral Genome Tethering and Persistence
Kaposi’s sarcoma associated herpesvirus is tightly linked to multiple human malignancies including Kaposi’s sarcoma (KS), Primary Effusion Lymphoma (PEL) and Multicentric Castleman’s Disease (MCD). KSHV like other herpesviruses ...
Blocking Apoptotic Signaling Rescues Axon Guidance in Netrin Mutants
Summary Netrins are guidance cues that form gradients to guide growing axons. We uncover a mechanism for axon guidance by demonstrating that axons can accurately navigate in the absence of a Netrin gradient if apoptotic ...
Stimulus Requirements for Face Perception: An Analysis Based on “Totem Poles”
The stimulus requirements for perceiving a face are not well defined but are presumably simple, for vivid faces can often by seen in random or natural images such as cloud or rock formations. To characterize these requirements, ...
Live well: a practical and effective low-intensity dietary counseling intervention for use in primary care patients with dyslipidemia--a randomized controlled pilot trial.
Background: Diet is the first line of treatment for elevated cholesterol. High-intensity dietary counseling (≥360 minutes/year of contact with providers) improves blood lipids, but is expensive and unsustainable in the ...
Large-scale molecular simulations of hypervelocity impact of materials
We describe the application of the ReaxFF reactive force field with short-range distance-dependent exponential inner wall corrections and the non-adiabatic electron Force Field (eFF) for studying the hypervelocity impact ...
Long-term survivorship of single-needle pinyon (Pinus monophylla) in mixed-conifer ecosystems of the Great Basin, USA
We examined stand structure and development of mixed‐conifer ecosystems in the south‐central Great Basin where pinyon (Pinus monophylla) and juniper (Juniperus osteosperma) are found together with other species, such as ...
Frax prediction without BMD for assessment of osteoporotic fracture risk.
To compare Fracture Risk Assessment Tool (FRAX) calculations with and without bone mineral density (BMD) in predicting the 10-year probability of hip and major osteoporotic fractures (MOF).
A Novel Cpu/Gpu Simulation Environment for Large-Scale Biologically Realistic Neural Modeling
Computational Neuroscience is an emerging field that provides unique opportunities to study complex brain structures through realistic neural simulations. However, as biological details are added to models, the execution ...
Shock response of a model structured nanofoam of Cu
(AIP Publishing, 2013)
Using large-scale molecular dynamics simulations, we investigate shock response of a model Cu nanofoam with cylindrical voids and a high initial porosity (50% theoretical density), including elastic and plastic deformation, ...
Shock response of single crystal and nanocrystalline pentaerythritol tetranitrate: Implications to hotspot formation in energetic materials.
(AIP Publishing, 2013)
We investigate shock response of single crystal and nanocrystalline pentaerythritol tetranitrate (PETN) with a coarse-grained model and molecular dynamics simulations, as regards mechanical hotspot formation in the absence ...