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Ancestral vinclozolin exposure alters the epigenetic transgenerational inheritance of sperm small noncoding RNAs
Exposure to the agricultural fungicide vinclozolin during gestation promotes a higher incidence of various diseases in the subsequent unexposed F3 and F4 generations. This phenomenon is termed epigenetic transgenerational ...
Escape of X-linked miRNA genes from meiotic sex chromosome inactivation
Past studies have indicated that transcription of all X-linked genes is repressed by meiotic sex chromosome inactivation (MSCI) during the meiotic phase of spermatogenesis in mammals. However, more recent studies have shown ...
Sperm-borne miRNAs and endo-siRNAs are important for fertilization and preimplantation embryonic development
Although it is believed that mammalian sperm carry small noncoding RNAs (sncRNAs) into oocytes during fertilization, it remains unknown whether these sperm-borne sncRNAs truly have any function during fertilization and ...
UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3 ' UTR Transcripts
During transcription, most eukaryotic genes generate multiple alternative cleavage and polyadenylation (APA) sites, leading to the production of transcript isoforms with variable lengths in the 3' untranslated region (3' ...
SpermBase: A Database for Sperm-Borne RNA Contents
Since their discovery approximately three decades ago, sperm-borne RNAs, both large/small and coding/noncoding, have been reported in multiple organisms, and some have been implicated in spermatogenesis, early development, ...
MicroRNAs control mRNA fate by compartmentalization based on 3 ' UTR length in male germ cells
Post-transcriptional regulation of gene expression can be achieved through the control of mRNA stability, cytoplasmic compartmentalization, 3' UTR length and translational efficacy. Spermiogenesis, a process through which ...
Paternal pachytene piRNAs are not required for fertilization, embryonic development and sperm-mediated epigenetic inheritance in mice
Pachytene piRNAs areMIWI-/MILI-bound small RNAs abundantly expressed in pachytene spermatocytes and round spermatids in adultmouse testes. Miwi knockout (KO) male mice are sterile due to spermiogenic arrest. In Caenorhabditis ...
MicroRNA-34/449 controls mitotic spindle orientation during mammalian cortex development
Correct orientation of the mitotic spindle determines the plane of cellular cleavage and is crucial for organ development. In the developing cerebral cortex, spindle orientation defects result in severe neurodevelopmental ...
Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice
Megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is a congenital visceral myopathy characterized by severe dilation of the urinary bladder and defective intestinal motility. The genetic basis of MMIHS has ...