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Single Molecule Analysis of Replicated DNA Reveals the Usage of Multiple KSHV Genome Regions for Latent Replication.
Kaposi's sarcoma associated herpesvirus (KSHV), an etiologic agent of Kaposi's sarcoma, Body Cavity Based Lymphoma and Multicentric Castleman's Disease, establishes lifelong latency in infected cells. The KSHV genome tethers ...
The RBP-J? binding sites within the RTA Promoter Regulates KSHV Latent Infection and Proliferation
Kaposi's sarcoma-associated herpesvirus (KSHV) is tightly linked to at least two lymphoproliferative disorders, primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). However, the development of ...
EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors
Cellular protein degradation pathways can be utilized by viruses to establish an environment that favors their propagation. Here we report that the Kaposi's sarcoma–associated herpesvirus (KSHV)-encoded latency-associated ...
Comprehensive Analysis of LANA Interacting Proteins Essential for Viral Genome Tethering and Persistence
Kaposi’s sarcoma associated herpesvirus is tightly linked to multiple human malignancies including Kaposi’s sarcoma (KS), Primary Effusion Lymphoma (PEL) and Multicentric Castleman’s Disease (MCD). KSHV like other herpesviruses ...
A Unique SUMO-2-Interacting Motif within LANA Is Essential for KSHV Latency
Kaposi's sarcoma-associated herpesvirus (KSHV) stabilizes hypoxia-inducible factor ? (HIF-1?) during latent infection, and HIF-1? reactivates lytic replication under hypoxic stress. However, the mechanism utilized by KSHV ...
Kaposi's sarcoma herpesvirus upregulates Aurora A expression to promote p53 phosphorylation and ubiquitylation
Aberrant expression of Aurora A kinase has been frequently implicated in many cancers and contributes to chromosome instability and phosphorylation-mediated ubiquitylation and degradation of p53 for tumorigenesis. Previous ...
Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification
The hypoxic microenvironment contributes to embryonic development and tumor progression through stabilization of the potent transcriptional factor HIF?. In normoxia, the tumor suppressor protein VHL acts as an E3 ubiquitin ...