Now showing items 1-6 of 6
Transcriptome of interstitial cells of Cajal reveals unique and selective gene signatures
Transcriptome-scale data can reveal essential clues into understanding the underlying molecular mechanisms behind specific cellular functions and biological processes. Transcriptomics is a continually growing field of ...
Transcriptome analysis of PDGFR alpha(+) cells identifies T-type Ca2+ channel CACNA1G as a new pathological marker for PDGFR alpha(+) cell hyperplasia
Platelet-derived growth factor receptor alpha (PDGFR alpha)(+) cells are distributed into distinct morphological groups within the serosal, muscular, and submucosal layers as well as the myenteric and deep muscular plexi. ...
DNA methylation, through DNMT1, has an essential role in the development of gastrointestinal smooth muscle cells and disease
DNA methylation is a key epigenetic modification that can regulate gene expression. Genomic DNA hypomethylation is commonly found in many gastrointestinal (GI) diseases. Dysregulated gene expression in GI smooth muscle ...
Serum response factor regulates smooth muscle contractility via myotonic dystrophy protein kinases and L-type calcium channels
Serum response factor (SRF) transcriptionally regulates expression of contractile genes in smooth muscle cells (SMC). Lack or decrease of SRF is directly linked to a phenotypic change of SMC, leading to hypomotility of ...
Serum Response Factor Is Essential for Prenatal Gastrointestinal Smooth Muscle Development and Maintenance of Differentiated Phenotype
Smooth muscle cells (SMCs) characteristically express serum response factor (SRF), which regulates their development. The role of SRF in SMC plasticity in the pathophysiological conditions of gastrointestinal (GI) tract ...
Smooth Muscle Transcriptome Browser: offering genome-wide references and expression profiles of transcripts expressed in intestinal SMC, ICC, and PDGFR alpha(+) cells
Transcriptome data on the quantitative numbers of transcriptional variants expressed in primary cells offer essential clues into specific cellular functions and biological processes. We have previously collected transcriptomes ...