Now showing items 1-3 of 3

  • .

    .

    .

    A germ-line deletion of APOBEC3B does not contribute to subtype-specific childhood acute lymphoblastic leukemia etiology 

    Wallace, Amelia D.; Francis, Stephen S.; Shao, Xiaorong; de Smith, Adam J.; Walsh, Kyle M.; McKean-Cowdin, Roberta; Ma, Xiaomei; Dahl, Gary; Barcellos, Lisa F.; Wiemels, Joseph L.; Metayer, Catherine (2018)
    Approximately 4/100,000 children are diagnosed with acute lymphoblastic leukemia (ALL) in the United States annually. Early life exposures related to immune priming (i.e. vaginal birth, daycare attendance, and high birth ...
  • .

    .

    .

    GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21 

    Wiemels, Joseph L.; Walsh, Kyle M.; de Smith, Adam J.; Metayer, Catherine; Gonseth, Semira; Hansen, Helen M.; Francis, Stephen S.; Ojha, Juhi; Smirnov, Ivan; Barcellos, Lisa F.; Xiao, Xiaorong; Morimoto, Libby; McKean-Cowdin, Roberta; Wang, Rong; Yu, Herbert; Hoh, Josephine; Dewan, Andrew T.; Ma, Xiaomei (Nature Communications, 2018)
    Childhood acute lymphoblastic leukemia (ALL) (age 0-14 years) is 20% more common in Latino Americans than non-Latino whites. We conduct a genome-wide association study in a large sample of 3263 Californian children with ...
  • .

    .

    .

    To ERV Is Human: A Phenotype-Wide Scan Linking Polymorphic Human Endogenous Retrovirus-K Insertions to Complex Phenotypes 

    Wallace, Amelia D.; Wendt, George A.; Barcellos, Lisa F.; de Smith, Adam J.; Walsh, Kyle M.; Metayer, Catherine; Costello, Joseph F.; Wiemels, Joseph L.; Francis, Stephen S. (2018)
    Approximately 8% of the human genome is comprised of endogenous retroviral insertions (ERVs) originating from historic retroviral integration into germ cells. The function of ERVs as regulators of gene expression is well ...