Now showing items 856-875 of 2136

  • .

    .

    .

    G-quadruplex-interacting compounds alter latent DNA replication and episomal persistence of KSHV 

    Madireddy, Advaitha; Purushothaman, Pravinkumar; Loosbroock, Christopher P.; Robertson, Erle S.; Schildkraut, Carl L.; Verma, Subhash C. (2016)
    Kaposi's sarcoma associated herpesvirus (KSHV) establishes life-long latent infection by persisting as an extra-chromosomal episome in the infected cells and by maintaining its genome in dividing cells. KSHV achieves this ...
  • .

    .

    .

    Galectin-1 Protein Therapy Prevents Pathology and Improves Muscle Function in the mdx Mouse Model of Duchenne Muscular Dystrophy 

    Van Ry, Pam M.; Wuebbles, Ryan D.; Key, Megan; Burkin, Dean J. (2015)
    Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disease caused by mutations in the dystrophin gene, leading to the loss of a critical component of the sarcolemmal dystrophin glycoprotein complex. Galectin-1 is ...
  • .

    .

    .

    Gastric and Duodenal Pseudomelanosis: An Extended Unusual Finding in a Patient with End Stage Kidney Disease 

    Qureshi, Noor U. A.; Younus, Muhammad F.; Alavi, Kourosh; Sheikh, Muhammad Y. (2016)
    Gastric and duodenal pseudomelanosis is a rare endoscopic mucosal finding, characterized by the accumulation of iron in macrophages of the lamina propria of the stomach and duodenum. The clinical significance and long term ...
  • .

    .

    .

    Gastrointestinal Beriberi and Wernicke's Encephalopathy Triggered by One Session of Heavy Drinking 

    Tjong, Elysia; Peng, Yen-Yi (Case Reports in Neurology, 2019)
    An otherwise healthy 30-year-old male acquired gastrointestinal beriberi and subsequent Wernicke's encephalopathy after 1 session of heavy drinking. Nausea, vomiting, and anorexia relentlessly progressed. The patient ...
  • .

    .

    .

    Gastrointestinal Bleed from Erosive Gastritis and Duodenitis: A Sentinel Event of Invasive Lobular Carcinoma of the Breast and a Diagnostic Dilemma 

    Ulanja, Mark B.; Taha, Mohamed E.; Al-Mashhadani, Arshad A.; Beutler, Bryce D.; Al-Tekreeti, Marwah M.; Elliott, Christie; Ambika, Santhosh (2018)
    Metastasis from breast cancer to the gastrointestinal (GI) tract is uncommon, and such events presenting as GI bleeding are exceedingly rare. In some individuals, the absence of classical findings of primary breast cancer ...
  • .

    .

    .

    Gender Differences in the Endowment Effect: Women Pay Less, but Won't Accept Less 

    Wieland, A.; Sundali, J.; Kemmelmeier, Markus; Sarin, R. (2014)
    We explore different contexts and mechanisms that might promote or alleviate the gender effect in risk aversion. Our main result is that we do not find gender differences in risk aversion when the choice is framed as a ...
  • .

    .

    .

    Gender Differences in Worry During Medical School 

    Miller, Grant D.; Kemmelmeier, Markus; Dupey, Peggy (2013)
    This research examined worry in medical students at various stages of training with reference to worries related to academic and clinical training, finances and relationships with peers. The study focused on gender differences ...
  • .

    .

    .

    Gender Moderates the Impact of Need for Structure on Social Beliefs: Implications for Ethnocentrism and Authoritarianism 

    Kemmelmeier, Markus (2010)
    The present research examines the interplay between individual differences in need for structure, social beliefs, and gender. It is well documented that need for structure, that is, a preference for structure and simplicity ...
  • .

    .

    .

    Gendered Influence of Downward Social Comparisons on Current and Possible Selves 

    Kemmelmeier, Markus; Oyserman, Daphna (2001)
    Because men and women differ with regard to independent and interdependent self‐construals, we propose that downward comparisons are more likely to lower women's achievement‐related self‐evaluations compared to men's. We ...
  • .

    .

    .

    Gene expression of the liver in response to chronic hypoxia. 

    Baze, Monica M.; Schlauch, Karen A.; Hayes, Jack P. (5/1/2010)
    Hypoxia is an important ecological, evolutionary, and biomedicalstressor. While physiological acclimatization of mammals to hypoxia is wellstudied, the variation in gene expression that underlies acclimatization is not ...
  • .

    .

    .

    Generation of electrophysiologically functional cardiomyocytes from mouse induced pluripotent stem cells 

    Wang, Hongran; Xi, Yutao; Zheng, Yi; Wang, Xiaohong; Cooney, Austin J. (2016)
    Induced pluripotent stem (iPS) cells can efficiently differentiate into the three germ layers similar to those formed by differentiated embryonic stem(ES) cells. This provides a new source of cells in which to establish ...
  • .

    .

    .

    Genetic Tools for the Analysis of Drosophila Stomatogastric Nervous System Development 

    Hernandez, Karla; Myers, Logan G.; Bowser, Micah; Kidd, Thomas (2015)
    The Drosophila stomatogastric nervous system (SNS) is a compact collection of neurons that arises from the migration of neural precursors. Here we describe genetic tools allowing functional analysis of the SNS during the ...
  • .

    .

    .

    Genetic variation and population structure in a threatened species, the Utah prairie dog Cynomys parvidens: the use of genetic data to inform conservation actions 

    Brown, Nathanael L.; Peacock, Mary M.; Ritchie, Mark E. (2016)
    The Utah prairie dog (Cynomys parvidens), listed as threatened under the United States Endangered Species Act, was the subject of an extensive eradication program throughout its range during the 20th century. Eradication ...
  • .

    .

    .

    Genome of the pitcher plant Cephalotus reveals genetic changes associated with carnivory 

    Fukushima, Kenji; Fang, Xiaodong; Alvarez-Ponce, David; Cai, Huimin; Carretero-Paulet, Lorenzo; Chen, Cui; Chang, Tien-Hao; Farr, Kimberly M.; Fujita, Tomomichi; Hiwatashi, Yuji; Hoshi, Yoshikazu; Imai, Takamasa; Kasahara, Masahiro; Librado, Pablo; Mao, Likai; Mori, Hitoshi; Nishiyama, Tomoaki; Nozawa, Masafumi; Palfalvi, Gergo; Pollard, Stephen T.; Rozas, Julio; Sanchez-Gracia, Alejandro; Sankoff, David; Shibata, Tomoko F.; Shigenobu, Shuji; Sumikawa, Naomi; Uzawa, Taketoshi; Xie, Meiying; Zheng, Chunfang; Pollock, David D.; Albert, Victor A.; Li, Shuaicheng; Hasebe, Mitsuyasu (2017)
    Carnivorous plants exploit animals as a nutritional source and have inspired long-standing questions about the origin and evolution of carnivory-related traits. To investigate the molecular bases of carnivory, we sequenced ...
  • .

    .

    .

    Genome Sequence Variability Predicts Drug Precautions and Withdrawals from the Market 

    Lee, Kye H.; Baik, Su Y.; Lee, Soo Y.; Park, Chanjae H.; Park, Paul J.; Kim, Ju H. (2016)
    Despite substantial premarket efforts, a significant portion of approved drugs has been withdrawn from the market for safety reasons. The deleterious impact of nonsynonymous substitutions predicted by the SIFT algorithm ...
  • .

    .

    .

    Genome-scale analysis of the genes that contribute to Burkholderia pseudomallei biofilm formation identifies a crucial exopolysaccharide biosynthesis gene cluster 

    Borlee, Grace I.; Plumley, Brooke A.; Martin, Kevin H.; Somprasong, Nawarat; Mangalea, Mihnea R.; Islam, M. Nurul; Burtnick, Mary N.; Brett, Paul J.; Steinmetz, Ivo; AuCoin, David P.; Belisle, John T.; Crick, Dean C.; Schweizer, Herbert P.; Borlee, Bradley R. (2017)
    Burkholderia pseudomallei, the causative agent of melioidosis, is an important public health threat due to limited therapeutic options for treatment. Efforts to improve therapeutics for B. pseudomallei infections are ...
  • .

    .

    .

    Genome-wide association analysis identifies common variants influencing infant brain volumes 

    Xia, K.; Zhang, J.; Ahn, Mihye; Jha, S.; Crowley, J. J.; Szatkiewicz, J.; Li, T.; Zou, F.; Zhu, H.; Hibar, D.; Thompson, P.; Sullivan, P. F.; Styner, M.; Gilmore, J. H.; Knickmeyer, R. C. (2017)
    Genome-wide association studies (GWAS) of adolescents and adults are transforming our understanding of how genetic variants impact brain structure and psychiatric risk, but cannot address the reality that psychiatric ...
  • .

    .

    .

    Genome-wide association analysis identifies genetic variations in subjects with myalgic encephalomyelitis/chronic fatigue syndrome 

    Schlauch, K. A.; Khaiboullina, Svetlana F.; De Meirleir, Kenny L.; Rawat, Shanti; Petereit, Julia; Rizvanov, A. A.; Blatt, N.; Mijatovic, Tatjana; Kulick, Doina; Palm, Kathleen M.; Lombardi, Vincent C. (2016)
    Myalgic encephalomyelitis, also known as chronic fatigue syndrome or ME/CFS, is a multifactorial and debilitating disease that has an impact on over 4 million people in the United States alone. The pathogenesis of ME/CFS ...
  • .

    .

    .

    Genomic Analysis of a Pan-Resistant Isolate of Klebsiella pneumoniae, United States 2016 

    de Man, Tom J. B.; Lutgring, Joseph D.; Lonsway, David R.; Anderson, Karen F.; Kiehlbauch, Julia A.; Chen, Lei; Walters, Maroya S.; Sjolund-Karlsson, Maria; Rasheed, J. Kamile; Kallen, Alexander; Halpin, Alison L. (2018)
    Antimicrobial resistance is a threat to public health globally and leads to an estimated 23,000 deaths annually in the United States alone. Here, we report the genomic characterization of an unusual Klebsiella pneumoniae, ...
  • .

    .

    .

    Genomic insights into the Ixodes scapularis tick vector of Lyme disease 

    Gulia-Nuss, Monika; Nuss, Andrew B.; Meyer, Jason M.; Sonenshine, Daniel E.; Roe, R. Michael; Waterhouse, Robert M.; Sattelle, David B.; de la Fuente, Jose; Ribeiro, Jose M.; Megy, Karine; Thimmapuram, Jyothi; Miller, Jason R.; Walenz, Brian P.; Koren, Sergey; Hostetler, Jessica B.; Thiagarajan, Mathangi; Joardar, Vinita S.; Hannick, Linda I.; Bidwell, Shelby; Hammond, Martin P.; Young, Sarah; Zeng, Qiandong; Abrudan, Jenica L.; Almeida, Francisca C.; Ayllon, Nieves; Bhide, Ketaki; Bissinger, Brooke W.; Bonzon-Kulichenko, Elena; Buckingham, Steven D.; Caffrey, Daniel R.; Caimano, Melissa J.; Croset, Vincent; Driscoll, Timothy; Gilbert, Don; Gillespie, Joseph J.; Giraldo-Calderon, Gloria I.; Grabowski, Jeffrey M.; Jiang, David; Khalil, Sayed M. S.; Kim, Donghun; Kocan, Katherine M.; Koci, Juraj; Kuhn, Richard J.; Kurtti, Timothy J.; Lees, Kristin; Lang, Emma G.; Kennedy, Ryan C.; Kwon, Hyeogsun; Perera, Rushika; Qi, Yumin; Radolf, Justin D.; Sakamoto, Joyce M.; Sanchez-Gracia, Alejandro; Severo, Maiara S.; Silverman, Neal; Simo, Ladislav; Tojo, Marta; Tornador, Cristian; Van Zee, Janice P.; Vazquez, Jesus; Vieira, Filipe G.; Villar, Margarita; Wespiser, Adam R.; Yang, Yunlong; Zhu, Jiwei; Arensburger, Peter; Pietrantonio, Patricia V.; Barker, Stephen C.; Shao, Renfu; Zdobnov, Evgeny M.; Hauser, Frank; Grimmelikhuijzen, Cornelis J. P.; Park, Yoonseong; Rozas, Julio; Benton, Richard; Pedra, Joao H. F.; Nelson, David R.; Unger, Maria F.; Tubio, Jose M. C.; Tu, Zhijian; Robertson, Hugh M.; Shumway, Martin; Sutton, Granger; Wortman, Jennifer R.; Lawson, Daniel; Wikel, Stephen K.; Nene, Vishvanath M.; Fraser, Claire M.; Collins, Frank H.; Birren, Bruce; Nelson, Karen E.; Caler, Elisabet; Hill, Catherine A. (2016)
    Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic ...