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Now showing items 1-8 of 8
Isolation and Cannulation of Cerebral Parenchymal Arterioles
Intracerebral parenchymal arterioles (PAs), which include parenchymal arterioles, penetrating arterioles and pre-capillary arterioles, are high resistance blood vessels branching out from pial arteries and arterioles and ...
Novel Redox-Dependent Esterase Activity (EC 188.8.131.52) for DJ-1: Implications for Parkinson's Disease
Mutations the in human DJ-1 (hDJ-1) gene are associated with early-onset autosomal recessive forms of Parkinson's disease (PD). hDJ-1/parkinsonism associated deglycase (PARK7) is a cytoprotective multi-functional protein ...
A Computational Modeling and Simulation Approach to Investigate Mechanisms of Subcellular cAMP Compartmentation
Subcellular compartmentation of the ubiquitous second messenger cAMP has been widely proposed as a mechanism to explain unique receptor-dependent functional responses. How exactly compartmentation is achieved, however, has ...
Mechanisms Restricting Diffusion of Intracellular cAMP
Although numerous receptors stimulate cAMP production in a wide array of cells, many elicit distinct, highly localized responses, implying that the subcellular distribution of cAMP is not uniform. One often used explanation ...
Mechanisms underlying prorenin actions on hypothalamic neurons implicated in cardiometabolic control
Hypertension and obesity are highly interrelated diseases, being critical components of the metabolic syndrome. Despite the growing prevalence of this syndrome in the world population, efficient therapies are still missing. ...
The critical role of the central nervous system (pro)renin receptor in regulating systemic blood pressure
The systemic renin-angiotensin system (RAS) has long been recognized as a critically important system in blood pressure (BP) regulation. However, extensive evidence has shown that a majority of RAS components are also ...
Insulin-like growth factors and their potential role in cardiac epigenetics
Cardiovascular disease (CVD) constitutes a major public health threat worldwide, accounting for 17.3 million deaths annually. Heart disease and stroke account for the majority of healthcare costs in the developed world. ...
Novel Biomarkers and Treatments of Cardiac Diseases
Cardiac diseases are mainly caused by malfunction of or injuries to the hearts. Although significant advances have been made during the past decades to improve the successful rate of treatments of these diseases, they ...