University of Nevada, Reno
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Microbiology and Immunology
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Welcome to the Department of Microbiology and Immunology at the University of Nevada, Reno. We are a community of 10 faculty, 30 senior scientists, postdoctoral fellows and graduate students and 15 support staff who are actively engaged in innovative research, discovery and education.
Research in the department focuses on immunology with an emphasis on cancer biology and microbial pathogenesis with a particular interest in emerging microbial infections and biodefense.
The department has an embedded culture that values training and education, be they in a formal classroom setting for professional and graduate students, at the laboratory bench, or one-on-one instruction and mentoring. This is an exciting time in biomedical research. Immunology is paving the way for treatment of diseases as diverse as cancer, Alzheimer's disease, autoimmunity and transplantation. New microbes are being discovered, and we are finding new relationships between the microbial world and an array of human diseases.
Take the opportunity to visit our site and view our contributions and your opportunities as we build the future in microbiology and immunology.
Theses and Dissertations for Microbiology and Immunology
Posters for Microbiology and Immunology
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Recent Submissions
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Next-Generation Sequencing in the Understanding of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Biology
(2016)Non-Sanger-based novel nucleic acid sequencing techniques, referred to as Next-Generation Sequencing (NGS), provide a rapid, reliable, high-throughput, and massively parallel sequencing methodology that has improved our ... -
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KSHV Genome Replication and Maintenance
(2016)Kaposi's sarcoma associated herpesvirus (KSHV) or human herpesvirus 8 (HHV8) is a major etiological agent for multiple severe malignancies in immune-compromised patients. KSHV establishes lifetime persistence in the infected ... -
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G-quadruplex-interacting compounds alter latent DNA replication and episomal persistence of KSHV
(2016)Kaposi's sarcoma associated herpesvirus (KSHV) establishes life-long latent infection by persisting as an extra-chromosomal episome in the infected cells and by maintaining its genome in dividing cells. KSHV achieves this ... -
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The Interaction between Viral and Environmental Risk Factors in the Pathogenesis of Multiple Sclerosis
(2019)Multiple sclerosis (MS) is a chronic debilitating inflammatory disease of unknown ethology targeting the central nervous system (CNS). MS has a polysymptomatic onset and is usually first diagnosed between the ages of 20-40 ... -
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Caprine humoral response to Burkholderia pseudomallei antigens during acute melioidosis from aerosol exposure
(2019)Burkholderia pseudomallei causes melioidosis, a common source of pneumonia and sepsis in Southeast Asia and Northern Australia that results in high mortality rates. A caprine melioidosis model of aerosol infection that ... -
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MicroRNA Post-transcriptional Regulation of the NLRP3 Inflammasome in Immunopathologies
(2019)Inflammation has a crucial role in protection against various pathogens. The inflammasome is an intracellular multiprotein signaling complex that is linked to pathogen sensing and initiation of the inflammatory response ... -
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KSHV lytic proteins K-RTA and K8 bind to cellular and viral chromatin to modulate gene expression
(2019)The oncogenic Kaposi's sarcoma-associated herpesvirus (KSHV) has two distinct life cycles with lifelong latent/non-productive and a sporadic lytic-reactivating/productive phases in the infected immune compromised human ... -
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Utility of a Lateral Flow Immunoassay (LFI) to Detect Burkholderia pseudomallei in Soil Samples
(2016)Background Culture is the gold standard for the detection of environmental B. pseudomallei. In general, soil specimens are cultured in enrichment broth for 2 days, and then the culture broth is streaked on an agar plate ... -
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KSHV-Mediated Angiogenesis in Tumor Progression
(2016)Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV), is a malignant human oncovirus belonging to the gamma herpesvirus family. HHV-8 is closely linked to the pathogenesis of Kaposi's ... -
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In vivo Distribution and Clearance of Purified Capsular Polysaccharide from Burkholderia pseudomallei in a Murine Model
(2016)Burkholderia pseudomallei is the causative agent of melioidosis, a severe infection prominent in northern Australia and Southeast Asia. The "gold standard" for melioidosis diagnosis is bacterial isolation, which takes ... -
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KSHV encoded LANA recruits Nucleosome Assembly Protein NAP1L1 for regulating viral DNA replication and transcription
(2016)The establishment of latency is an essential for lifelong persistence and pathogenesis of Kaposi's sarcoma-associated herpesvirus (KSHV). Latency-associated nuclear antigen (LANA) is the most abundantly expressed protein ... -
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Host Immune Response to ZIKV in an Immunocompetent Embryonic Mouse Model of Intravaginal Infection
(2019)Zika virus (ZIKV) only induces mild symptoms in adults -
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Serum Cytokine Profiles in Children with Crohn's Disease
(2016)Crohn's disease (CD) is a chronic inflammatory bowel disease that can be diagnosed at any age. There are two major patient groups based on diagnosis of this disease, before or after the age of 20 (juvenile/adolescent or ... -
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Transcriptome Profiling Reveals Pro-Inflammatory Cytokines and Matrix Metalloproteinase Activation in Zika Virus Infected Human Umbilical Vein Endothelial Cells
(2019)The deformities in the newborns infected with Zika virus (ZIKV) present a new potential public health threat to the worldwide community. Although ZIKV infection is mainly asymptomatic in healthy adults, infection during ... -
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Metadherin: A Therapeutic Target in Multiple Cancers
(2019)Altered expression of many genes and proteins is essential for cancer development and progression. Recently, the affected expression of metadherin (MTDH), also known as AEG-1 (Astrocyte Elevated Gene 1) and Lyric, has been ... -
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Hantavirus Infection Suppresses Thrombospondin-1 Expression in Cultured Endothelial Cells in a Strain-Specific Manner
(2016)Hantavirus infection is associated with two frequently fatal diseases in humans: Hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). The pathogenesis of hantavirus infection is complex and ... -
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Prevalence of Sickle Cell Trait and Reliability of Self-Reported Status among Expectant Parents in Nigeria: Implications for Targeted Newborn Screening
(2016)Sickle cell disease (SCD) is a life-threatening, autosomal recessive blood disorder prevalent in sub-Saharan Africa. We identified the prevalence of sickle cell trait (SCT) among pregnant women and their male partners in ... -
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Contribution of murine IgG Fc regions to antibody binding to the capsule of Burkholderia pseudomallei
(2016)Immunoglobulin G3 (IgG3) is the predominant IgG subclass elicited in response to polysaccharide antigens in mice. This specific subclass has been shown to crosslink its fragment crystallizable (Fc) regions following binding ... -
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Multi-platform Approach for Microbial Biomarker Identification Using Borrelia burgdorferi as a Model
(2019)The identification of microbial biomarkers is critical for the diagnosis of a disease early during infection. However, the identification of reliable biomarkers is often hampered by a low concentration of microbes or ...
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