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Now showing items 1-10 of 13
What lies beneath? Molecular evolution during the radiation of caecilian amphibians
(2019)
Evolution leaves an imprint in species through genetic change. At the molecular level, evolutionary changes can be explored by studying ratios of nucleotide substitutions. The interplay among molecular evolution, derived ...
Position Matters: Network Centrality Considerably Impacts Rates of Protein Evolution in the Human Protein-Protein Interaction Network
(2017)
The proteins of any organism evolve at disparate rates. A long list of factors affecting rates of protein evolution have been identified. However, the relative importance of each factor in determining rates of protein ...
Chance and necessity in the genome evolution of endosymbiotic bacteria of insects
(2017)
An open question in evolutionary biology is how does the selection-drift balance determine the fates of biological interactions. We searched for signatures of selection and drift in genomes of five endosymbiotic bacterial ...
Phylogenetic Distribution of CMP-Neu5Ac Hydroxylase (CMAH), the Enzyme Synthetizing the Proinflammatory Human Xenoantigen Neu5Gc
(2018)
The enzyme CMP-N-acetylneuraminic acid hydroxylase (CMAH) is responsible for the synthesis of N-glycolylneuraminic acid ( Neu5Gc), a sialic acid present on the cell surface proteins of most deuterostomes. The CMAH gene is ...
Genome of the pitcher plant Cephalotus reveals genetic changes associated with carnivory
(2017)
Carnivorous plants exploit animals as a nutritional source and have inspired long-standing questions about the origin and evolution of carnivory-related traits. To investigate the molecular bases of carnivory, we sequenced ...
Essentiality Is a Strong Determinant of Protein Rates of Evolution during Mutation Accumulation Experiments in Escherichia coli
(2016)
The Neutral Theory of Molecular Evolution is considered the most powerful theory to understand the evolutionary behavior of proteins. One of the main predictions of this theory is that essential proteins should evolve ...
The Molecular Chaperone DnaK Is a Source of Mutational Robustness
(2016)
Molecular chaperones, also known as heat-shock proteins, refold misfolded proteins and help other proteins reach their native conformation. Thanks to these abilities, some chaperones, such as the Hsp90 protein or the ...
Positive Selection and Centrality in the Yeast and Fly Protein-Protein Interaction Networks
(3/28/2016)
Proteins within a molecular network are expected to be subject to different selective pressures depending on their relative hierarchical positions. However, it is not obvious what genes within a network should be more ...
Molecular evolution of DNMT1 in vertebrates: Duplications in marsupials followed by positive selection
(2018)
DNA methylation is mediated by a conserved family of DNA methyltransferases (Dnmts). The human genome encodes three active Dnmts (Dnmt1, Dnmt3a and Dnmt3b), the tRNA methyltransferase Dnmt2, and the regulatory protein ...
High quality draft genome sequence of &ITMycoplasma testudineum&IT strain BH29(T), isolated from the respiratory tract of a desert tortoise
(2018)
Mycoplasma testudineum is one of the pathogens that can cause upper respiratory tract disease in desert tortoises, Gopherus agassizii. We sequenced the genome of M. testudineum BH29(T) (ATCC 700618(T) = MCCM 03231(T)), ...