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Biochemistry and Molecular Biology
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The mission of the Department of Biochemistry and Molecular Biology is to provide strong educational programs for undergraduate, graduate, and professional students, to conduct high quality research in biochemistry, molecular biology and biotechnology, and to effectively transmit scientific knowledge to the general public.
Theses and Dissertations for Biochemistry and Molecular Biology
Posters for Biochemistry and Molecular Biology
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The final piece of the Triangle of U: Evolution of the tetraploid Brassica carinata genome
(The Plant Cell, 2022-08-12)Ethiopian mustard (Brassica carinata) is an ancient crop with remarkable stress resilience and a desirable seed fatty acid profile for biofuel uses. Brassica carinata is one of six Brassica species that share three major ... -
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Mitochondrial haplotypes are not associated with mice selectively bred for high voluntary wheel running
(2019)Mitochondrial haplotypes have been associated with human and rodent phenotypes, including nonshiveringthermogenesis capacity, learning capability, and disease risk. Although the mammalian mitochondrial D-loop ishighly ... -
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Biology and chemistry of an Umbravirus like 2989 bp single stranded RNA as a possible causal agent for Opuntia stunting disease (engrosamiento de cladodios)-A Review.
(2019)Perhaps the most economically important disease of Opuntia ficus indica fruit cacti in Mexico is the “engrosamiento de cladodios” or macho disease. The symptoms of this disease, which has been suggested to be caused by ... -
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The bracteatus pineapple genome and domestication of clonally propagated crops
(2019)Domestication of clonally propagated crops such as pineapple from South America was hypothesized to be a ‘one-step operation’. We sequenced the genome of Ananas comosus var. bracteatus CB5 and assembled 513?Mb into 25 ... -
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Evolution of l‐DOPA 4,5‐dioxygenase activity allows for recurrent specialisation to betalain pigmentation in Caryophyllales
(2019)The evolution of L-DOPA 4, 5-dioxygenase activity, encoded by the gene DODA, was a keystep in the origin of betalain biosynthesis in Caryophyllales. We previously proposed that L-DOPA 4,5-dioxygenase activity evolved via ... -
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Identification of genes encoding enzymes catalyzing the early steps of carrot polyacetylene biosynthesis
(2018)Polyacetylenic lipids accumulate in various Apiaceae species after pathogen attack, suggesting that these compounds are naturally occurring pesticides and potentially valuable resources for crop improvement. These compounds ... -
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Crassulacean Acid Metabolism Abiotic Stress-Responsive Transcription Factors: a Potential Genetic Engineering Approach for Improving Crop Tolerance to Abiotic Stress
(2019)This perspective paper explores the utilization of abiotic stress-responsive transcription factors (TFs) from crassulacean acid metabolism (CAM) plants to improve abiotic stress tolerance in crop plants. CAM is a specialized ... -
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Laying the foundation for crassulacean acid metabolism (CAM) Biodesign: Expression of the C4 metabolism cycle genes of CAM in Arabidopsis.
(2019)Crassulacean acid metabolism (CAM) is a specialized mode of photosynthesis that exploits a temporal CO2 pump with nocturnal CO2 uptake and concentration to reduce photorespiration, improve water-use efficiency (WUE), and ... -
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Hantavirus Infection Suppresses Thrombospondin-1 Expression in Cultured Endothelial Cells in a Strain-Specific Manner
(2016)Hantavirus infection is associated with two frequently fatal diseases in humans: Hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). The pathogenesis of hantavirus infection is complex and ... -
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Desiccation tolerance in Anopheles coluzzii: the effects of spiracle size and cuticular hydrocarbons
(2016)The African malaria mosquitoes Anopheles gambiae and Anopheles coluzzii range over forests and arid areas, where they withstand dry spells and months-long dry seasons, suggesting variation in their desiccation tolerance. ... -
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Boosting Hematopoietic Engraftment after in Utero Transplantation through Vascular Niche Manipulation
(2016)In utero hematopoietic stem/progenitor cell transplantation (IUHSCT) has only been fully successful in the treatment of congenital immunodeficiency diseases. Using sheep as a large animal model of IUHSCT, we demonstrate ... -
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Identification of Ice Plant (Mesembryanthemum crystallinum L.) MicroRNAs Using RNA-Seq and Their Putative Roles in High Salinity Responses in Seedlings
(2016)The halophyte Mesembryanthemum crystal/loom (common or crystalline ice plant) is a useful model for studying molecular mechanisms of salt tolerance. The morphology, physiology, metabolism, and gene expression of ice plant ... -
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Relative quantification of phosphoproteomic changes in grapevine (Vitis vinifera L.) leaves in response to abscisic acid
(2016)In a previous transcriptomic analysis, abscisic acid (ABA) was found to affect the abundance of a number of transcripts in leaves of Cabernet Sauvignon grapevines with roots that had been exposed to 10 mu M ABA for 2 h. ... -
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Drosophila Spidey/Kar Regulates Oenocyte Growth via PI3-Kinase Signaling
(2016)Cell growth and proliferation depend upon many different aspects of lipid metabolism. One key signaling pathway that is utilized in many different anabolic contexts involves Phosphatidylinositide 3-kinase (PI3K) and its ... -
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Transcriptomic network analyses of leaf dehydration responses identify highly connected ABA and ethylene signaling hubs in three grapevine species differing in drought tolerance
(2016)Grapevine is a major food crop that is affected by global climate change. Consistent with field studies, dehydration assays of grapevine leaves can reveal valuable information of the plant's response at physiological, ... -
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Transcriptomic response is more sensitive to water deficit in shoots than roots of Vitis riparia (Michx.)
(2019)Drought is an important constraint on grapevine sustainability. Vitis riparia, widely used in rootstock and scion breeding, has been studied in isolated leaf drying response studies however, it is essential to identify key ... -
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Dynamics of Insulin Signaling in the Black-Legged Tick, Ixodes scapularis
(2019)Insulin-like peptides (ILPs) have been identified in several invertebrates, particularly insects, and work on these ILPs has revealed many roles including regulation of energy homeostasis, growth, development, and lifespan ... -
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Insulin-Like Peptide Signaling in Mosquitoes: The Road Behind and the Road Ahead
(2019)Insulin signaling is a conserved pathway in all metazoans. This pathway contributed toward primordial metazoans responding to a greater diversity of environmental signals by modulating nutritional storage, reproduction, ... -
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Crassulacean Acid Metabolism Abiotic Stress-Responsive Transcription Factors: a Potential Genetic Engineering Approach for Improving Crop Tolerance to Abiotic Stress
(2019)This perspective paper explores the utilization of abiotic stress-responsive transcription factors (TFs) from crassulacean acid metabolism (CAM) plants to improve abiotic stress tolerance in crop plants. CAM is a specialized ... -
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Cytochrome P450 associated with insecticide resistance catalyzes cuticular hydrocarbon production in Anopheles gambiae
(2016)The role of cuticle changes in insecticide resistance in the major malaria vector Anopheles gambiae was assessed. The rate of internalization of C-14 deltamethrin was significantly slower in a resistant strain than in a ...
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