University of Nevada, Reno
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Physiology and Cell Biology
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Research in the Department of Physiology & Cell Biology focuses on smooth muscle biology, ion channels, neuropharmacology, gastric motility, developmental neuroscience, and reproductive biology. Our Department ranks highest in extramural research funding among the Departments of the School of Medicine at the University of Nevada, Reno, as well as in the number of scientific articles published. The Department contributes to several NIH-funded Program grants such as Centers of Biomedical Research Excellence ("COBREs") Smooth Muscle and Cell Biology, IDeA Network of Biomedical Research Excellence (INBRE) and a Program Project Grant (PPG) (in its 23rd year). Department Faculty Members publish between 30 and 50 peer-reviewed, PubMed-archived articles each year, including top journals in the field. The Department is responsible for 72% of the curriculum of our first-year medical students, and supports graduate student education in several programs, primarily the Cellular and Molecular Pharmacology and Physiology (CMPP) program which attracts and trains excellent students. In addition, the Department trains undergraduate students in an international student exchange program. Several Department faculty have been elected to perform editorial responsibilities.
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Recent Submissions
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Genome Sequence Variability Predicts Drug Precautions and Withdrawals from the Market
(2016)Despite substantial premarket efforts, a significant portion of approved drugs has been withdrawn from the market for safety reasons. The deleterious impact of nonsynonymous substitutions predicted by the SIFT algorithm ... -
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SpermBase: A Database for Sperm-Borne RNA Contents
(2016)Since their discovery approximately three decades ago, sperm-borne RNAs, both large/small and coding/noncoding, have been reported in multiple organisms, and some have been implicated in spermatogenesis, early development, ... -
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Glycine triggers a non-ionotropic activity of GluN2A-containing NMDA receptors to confer neuroprotection
(2016)Ionotropic activation of NMDA receptors (NMDARs) requires agonist glutamate and co-agonist glycine. Here we show that glycine enhances the activation of cell survival-promoting kinase Akt in cultured cortical neurons in ... -
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Glycine Potentiates AMPA Receptor Function through Metabotropic Activation of GIuN2A-Containing NMDA Receptors
(2016)NMDA receptors are Ca2+.-permeable ion channels. The activation of NMDA receptors requires agonist glutamate and co-agonist glycine. Recent evidence indicates that NMDA receptor also has metabotropic function. Here we ... -
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Smooth Muscle Transcriptome Browser: offering genome-wide references and expression profiles of transcripts expressed in intestinal SMC, ICC, and PDGFR alpha(+) cells
(2019)Transcriptome data on the quantitative numbers of transcriptional variants expressed in primary cells offer essential clues into specific cellular functions and biological processes. We have previously collected transcriptomes ... -
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Environmental Toxicant Induced Epigenetic Transgenerational Inheritance of Prostate Pathology and Stromal-Epithelial Cell Epigenome and Transcriptome Alterations: Ancestral Origins of Prostate Disease
(2019)Prostate diseases include prostate cancer, which is the second most common male neoplasia, and benign prostatic hyperplasia (BPH), which affects approximately 50% of men. The incidence of prostate disease is increasing, ... -
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Glial cells maintain synapses by inhibiting an activity-dependent retrograde protease signal
(2019)Glial cells regulate multiple aspects of synaptogenesis. In the absence of Schwann cells, a peripheral glial cell, motor neurons initially innervate muscle but then degenerate. Here, using a genetic approach, we show that ... -
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The expanding repertoire of hereditary information carriers
(2019)A hereditary system that is based on double-helix DNA sequences provides a stable way to store inherited traits and is favored by most life forms on Earth. However, emerging studies on the phenomenon of non-DNA sequence-based ... -
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Prediction of itching diagnostic marker through RNA sequencing of contact hypersensitivity and skin scratching stimulation mice models
(2019)Pruritus (itching) is classically defined as an unpleasant cutaneous sensation that leads to scratching behavior. Although the scientific criteria of classification for pruritic diseases are not clear, it can be divided ... -
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Expression profiling elucidates a molecular gene signature for pulmonary hypertension in sarcoidosis
(2016)Pulmonary hypertension (PH), when it complicates sarcoidosis, carries a poor prognosis, in part because it is difficult to detect early in patients with worsening respiratory symptoms. Pathogenesis of sarcoidosis occurs ... -
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Paternal pachytene piRNAs are not required for fertilization, embryonic development and sperm-mediated epigenetic inheritance in mice
(2016)Pachytene piRNAs areMIWI-/MILI-bound small RNAs abundantly expressed in pachytene spermatocytes and round spermatids in adultmouse testes. Miwi knockout (KO) male mice are sterile due to spermiogenic arrest. In Caenorhabditis ... -
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MicroRNA-34/449 controls mitotic spindle orientation during mammalian cortex development
(2016)Correct orientation of the mitotic spindle determines the plane of cellular cleavage and is crucial for organ development. In the developing cerebral cortex, spindle orientation defects result in severe neurodevelopmental ... -
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Insertion of a chimeric retrotransposon sequence in mouse Axin1 locus causes metastable kinky tail phenotype
(2019)Transposable elements (TEs) make up >50% of the human genome, and the majority of retrotransposon insertions are truncated and many are located in introns. However, the effects of retrotransposition on the host genes remain ... -
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KCa3.1 Transgene Induction in Murine Intestinal Epithelium Causes Duodenal Chyme Accumulation and Impairs Duodenal Contractility
(2019)The epithelial intermediate-conductance calcium/calmodulin-regulated KCa3.1 channel is considered to be a regulator of intestine function by controlling chloride secretion and water/salt balance. Yet, little is known about ... -
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Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice
(2019)Potassium (K+) channels shape the response properties of neurons. Although enormous progress has been made to characterize K+ channels in the primary auditory neurons, the molecular identities of many of these channels and ... -
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Mechanisms of Calmodulin Regulation of Different Isoforms of Kv7.4 K+ Channels
(2016)Calmodulin (CaM), a Ca2+-sensing protein, is constitutively bound to IQ domains of the C termini of human Kv7 (hKv7, KCNQ) channels to mediate Ca2+-dependent reduction of Kv7 currents. However, the mechanism remains unclear. ... -
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Ancestral vinclozolin exposure alters the epigenetic transgenerational inheritance of sperm small noncoding RNAs
(2016)Exposure to the agricultural fungicide vinclozolin during gestation promotes a higher incidence of various diseases in the subsequent unexposed F3 and F4 generations. This phenomenon is termed epigenetic transgenerational ... -
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A Novel Striated Muscle-Specific Myosin-Blocking Drug for the Study of Neuromuscular Physiology
(2016)The failure to transmit neural action potentials (APs) into muscle APs is referred to as neuromuscular transmission failure (NTF). Although synaptic dysfunction occurs in a variety of neuromuscular diseases and impaired ... -
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Deletion of the Ca2+ Channel Subunit alpha(2)delta 3 Differentially Affects Ca(v)2.1 and Ca(v)2.2 Currents in Cultured Spiral Ganglion Neurons Before and After the Onset of Hearing
(2019)Voltage-gated Ca2+ channels are composed of a pore-forming alpha(1) subunit and auxiliary beta and alpha(2)delta subunits, which modulate Ca2+ current properties and channel trafficking. So far, the partial redundancy and ...
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