University of Nevada, Reno
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Pharmacology
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Pharmacology is the study of the therapeutic value and potential toxicity of chemical agents on biological systems. It targets every aspect of the mechanisms for the chemical actions of both traditional and novel therapeutic agents. The University of Nevada, Reno School of Medicine Department of Pharmacology is committed to excellence in both teaching and research.
The Department of Pharmacology is located within the University of Nevada, Reno School of Medicine at the north end of campus which is in the foothills of the eastern Sierra Nevada mountain range.
Theses and Dissertations for Pharmacology
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Isolation and Cannulation of Cerebral Parenchymal Arterioles
(2016)Intracerebral parenchymal arterioles (PAs), which include parenchymal arterioles, penetrating arterioles and pre-capillary arterioles, are high resistance blood vessels branching out from pial arteries and arterioles and ... -
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A Computational Modeling and Simulation Approach to Investigate Mechanisms of Subcellular cAMP Compartmentation
(2016)Subcellular compartmentation of the ubiquitous second messenger cAMP has been widely proposed as a mechanism to explain unique receptor-dependent functional responses. How exactly compartmentation is achieved, however, has ... -
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Mechanisms Restricting Diffusion of Intracellular cAMP
(2016)Although numerous receptors stimulate cAMP production in a wide array of cells, many elicit distinct, highly localized responses, implying that the subcellular distribution of cAMP is not uniform. One often used explanation ... -
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Mechanisms underlying prorenin actions on hypothalamic neurons implicated in cardiometabolic control
(2016)Hypertension and obesity are highly interrelated diseases, being critical components of the metabolic syndrome. Despite the growing prevalence of this syndrome in the world population, efficient therapies are still missing. ... -
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The critical role of the central nervous system (pro)renin receptor in regulating systemic blood pressure
(2016)The systemic renin-angiotensin system (RAS) has long been recognized as a critically important system in blood pressure (BP) regulation. However, extensive evidence has shown that a majority of RAS components are also ... -
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Novel Biomarkers and Treatments of Cardiac Diseases
(2016)Cardiac diseases are mainly caused by malfunction of or injuries to the hearts. Although significant advances have been made during the past decades to improve the successful rate of treatments of these diseases, they ... -
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Insulin-like growth factors and their potential role in cardiac epigenetics
(2016)Cardiovascular disease (CVD) constitutes a major public health threat worldwide, accounting for 17.3 million deaths annually. Heart disease and stroke account for the majority of healthcare costs in the developed world. ... -
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Novel Redox-Dependent Esterase Activity (EC 3.1.1.2) for DJ-1: Implications for Parkinson's Disease
(2016)Mutations the in human DJ-1 (hDJ-1) gene are associated with early-onset autosomal recessive forms of Parkinson's disease (PD). hDJ-1/parkinsonism associated deglycase (PARK7) is a cytoprotective multi-functional protein ... -
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Ion channel gene expression predicts survival in glioma patients
(2015)Ion channels are important regulators in cell proliferation, migration, and apoptosis. The malfunction and/or aberrant expression of ion channels may disrupt these important biological processes and influence cancer ... -
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Functional and Structural Consequence of Rare Exonic Single Nucleotide Polymorphisms: One Story, Two Tales
(2015)Genetic variation arising from single nucleotide polymorphisms (SNPs) is ubiquitously found among human populations. While disease-causing variants are known in some cases, identifying functional or causative variants for ... -
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Galectin-1 Protein Therapy Prevents Pathology and Improves Muscle Function in the mdx Mouse Model of Duchenne Muscular Dystrophy
(2015)Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disease caused by mutations in the dystrophin gene, leading to the loss of a critical component of the sarcolemmal dystrophin glycoprotein complex. Galectin-1 is ... -
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LC/MS/MS data analysis of the human uterine smooth muscle S-nitrosoproteome fingerprint in pregnancy, labor, and preterm labor
(2015)The data described in this article is the subject of an article in the American Journal of Physiology: Cell Physiology, titled The Human Uterine Smooth Muscle S-nitrosoproteome Fingerprint in Pregnancy, Labor, and Preterm ... -
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Alternatively Spliced Human TREK-1 Variants Alter TREK-1 Channel Function and Localization
(2015)TREK-1, an outward-rectifying potassium channel activated by stretch, is found in the myometrium of pregnant women. Decreased expression of TREK-1 near term suggests that TREK-1 may contribute to uterine quiescence during ... -
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Naja naja oxiana Cobra Venom Cytotoxins CTI and CTII Disrupt Mitochondrial Membrane Integrity: Implications for Basic Three-Fingered Cytotoxins
(2015)Cobra venom cytotoxins are basic three-fingered, amphipathic, non-enzymatic proteins that constitute a major fraction of cobra venom. While cytotoxins cause mitochondrial dysfunction in different cell types, the mechanisms ... -
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Unitary TRPV3 channel Ca2+ influx events elicit endothelium-dependent dilation of cerebral parenchymal arterioles
(2015)Cerebral parenchymal arterioles (PA) regulate blood flow between pial arteries on the surface of the brain and the deeper microcirculation. Regulation of PA contractility differs from that of pial arteries and is not ... -
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Renal medullary (pro)renin receptor contributes to angiotensin II-induced hypertension in rats via activation of the local renin-angiotensin system
(2015)(Pro) renin receptor (PRR) is a new component of the renin-angiotensin system and regulates renin activity in vitro. Within the kidney, PRR is highly expressed in the renal medulla where its expression is induced by ... -
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Naja mossambica mossambica Cobra Cardiotoxin Targets Mitochondria to Disrupt Mitochondrial Membrane Structure and Function
(Toxins, 2019)Cobra venom cardiotoxins (CVCs) can translocate to mitochondria to promote apoptosis by eliciting mitochondrial dysfunction. However, the molecular mechanism(s) by which CVCs are selectively targeted to the mitochondrion ... -
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Human Galectin-1 Improves Sarcolemma Stability and Muscle Vascularization in the mdx Mouse Model of Duchenne Muscular Dystrophy
(Molecular Therapy - Methods and Clinical Development, 2019)Duchenne muscular dystrophy (DMD) is a devastating disease caused by mutations in the dystrophin gene that result in the complete absence of dystrophin protein. We have shown previously that recombinant mouse Galectin-1 ... -
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A cre-inducible DUX4 transgenic mouse model for investigating facioscapulohumeral muscular dystrophy
(2018)The Double homeobox 4 (DUX4) gene is an important regulator of early human development and its aberrant expression is causal for facioscapulohumeral muscular dystrophy (FSHD). The DUX4-full length (DUX4-fl) mRNA splice ... -
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Different Membrane Pathways Mediate Ca2+ Influx in Adrenal Chromaffin Cells Exposed to 150-400 ns Electric Pulses
(2018)Exposing adrenal chromaffin cells to 5 ns electric pulses (nsPEF) causes a rapid rise in intracellular Ca2+ ([Ca2+] i) that is solely the result of Ca2+ influx through voltage-gated Ca2+ channels (VGCCs). This study explored ...
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