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Now showing items 4092-4111 of 7606
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K-12 Curriculum and Robotics to Address the Workforce Shortage and Advancement of Computing
(2018)Development and novel research contributions for computing and robotics technologies requires a workforce with mastery of computing. However, this goal is currently strained due to issues of education, access, and discernment ... -
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K-8 Teachers' Self-Efficacy Beliefs for Teaching Mathematics
(2013)AbstractMathematics knowledge and skills serve as the "gatekeeper" to students' choice of college majors, success obtaining college degrees, and entry into the workforce. However, on the mathematics portion of standardized ... -
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K-Theory for AF Algebras
(2014)K-theory for C*-algebras provides a means ofestablishing stable and complete*-isomorphism invariants.This work reestablishes the results of Elliot, Dixmier, Bratteli andElliot pertaining to the formation of a complete ... -
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Kaposi Sarcoma Herpes Virus Latency Associated Nuclear Antigen Protein Release the G2/M Cell Cycle Blocks by Modulating ATM/ATR Mediated Checkpoint Pathway
(2014)The Kaposi's sarcoma-associated herpesvirus infects the human population and maintains latency stage of viral life cycle in a variety of cell types including cells of epithelial, mesenchymal and endothelial origin. The ... -
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Kaposi's sarcoma herpesvirus upregulates Aurora A expression to promote p53 phosphorylation and ubiquitylation
(2012)Aberrant expression of Aurora A kinase has been frequently implicated in many cancers and contributes to chromosome instability and phosphorylation-mediated ubiquitylation and degradation of p53 for tumorigenesis. Previous ... -
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Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein.
(2007)Deregulation of the evolutionarily conserved Notch signaling is highly correlated with oncogenesis. Intracellular activated Notch (ICN) is a protooncogene linked to the transcription activation of a number of cellular genes ... -
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Kaposi's Sarcoma-Associated Herpesvirus Genome Programming during the Early Stages of Primary Infection of Peripheral Blood Mononuclear Cells
(2014)The early period of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection involves the dynamic expression of viral genes, which are temporally and epigenetically regulated. KSHV can effectively infect and persist in ... -
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Kaposi's sarcoma-associated herpesvirus inhibits interleukin-4-mediated STAT6 phosphorylation to regulate apoptosis and maintain latency
(2010)Cytokine-mediated JAK/STAT signaling controls numerous important biologic responses like immune function, cellular growth, and differentiation. Inappropriate activation of this signaling pathway is associated with a range ... -
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Kaposi's sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1 alpha to upregulate RTA expression during hypoxia: Latency control under low oxygen conditions
(2006)Hypoxia can induce lytic replication of Kaposi's sarcoma-associated herpesvirus (KSHV) in primary effusion lymphoma (PEL) cells. However, the molecular mechanism of lytic reactivation of KSHV by hypoxia remains unclear. ... -
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Kaposi's sarcoma-associated herpesvirus-encoded LANA can interact with the nuclear mitotic apparatus protein to regulate genome maintenance and segregation
(2008)Kaposi's sarcoma-associated herpesvirus (KSHV) genomes are tethered to the host chromosomes and partitioned faithfully into daughter cells with the host chromosomes. The latency-associated nuclear antigen (LANA) is important ... -
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Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Recruits Topoisomerase IIβ for Latent DNA Replication of the Terminal Repeats
(2012)The latency-associated nuclear antigen (LANA) encoded by Kaposi's sarcoma-associated herpesvirus (KSHV) plays a major role in maintaining latency and is critical for the perpetual segregation of viral episomes to the progeny ... -
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Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: a potential mechanism for virus-mediated control of latency.
(2004)Like other herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV, also designated human herpesvirus 8) can establish a latent infection in the infected host. During latency a small number of genes are expressed. One ... -
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Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen modulates K1 expression through its cis-acting elements within the terminal repeats.
(2006)K1 is the first open reading frame encoded by Kaposi's sarcoma-associated herpesvirus (KSHV) and lies positionally to the immediate right of the terminal repeats. K1 is a transmembrane glycoprotein having a functional ... -
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Kaposi's Sarcoma: Literature Review on the Mechanism of Kaposi's Sarcoma encoded Latency-Associated Nuclear Antigen and a Clinical Case Study
(2013)Whether genetic, geographic, or acquired; a multitude of factors can bring about Herpesvirus 8 induced Kaposi’s Sarcoma, of which four subtypes have been identified: Classic, African endemic, AIDS-related, and iatrogenic ... -
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Kashpar : the saga of the Basque immigrants to North America
(Center for Basque Studies, 2014)This book is the story of Joe Eiguren, an average Basque immigrant to the United States, who came seeking a new life when the Basque Country was devastated by the political terror exerted from the Spanish government before ... -
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KCa3.1 Transgene Induction in Murine Intestinal Epithelium Causes Duodenal Chyme Accumulation and Impairs Duodenal Contractility
(2019)The epithelial intermediate-conductance calcium/calmodulin-regulated KCa3.1 channel is considered to be a regulator of intestine function by controlling chloride secretion and water/salt balance. Yet, little is known about ... -
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Keeping Up Appearances: Cosmetics in Sulphur, Nevada
(2011)Sulphur, Nevada is an abandoned mining settlement in northwestern Nevada that was settled in the early 20th century. Archaeological work conducted at the site in 2009 and 2010 revealed the presence of an unusual number ... -
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Kelvin-Helmholtz Instability in Magnetized Plasma
(2012)Sheared flows, found in many systems in the universe, are generally Kelvin-Helmholtz unstable. If the medium is ionized, the presence of a magnetic field can influence the evolution of this instability; depending on its ... -
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Keystone: A Streaming Data Management Model for the Environmental Sciences
(2019)In this thesis we explore a problem facing contemporary data management in the earth and environmental sciences: effective production of uniform and quality data products which keeps pace with the volume and velocity of ... -
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Khovanov Homology on Symmetric Unions of Certain 2-Bridge Knots
(2011)Symmetric unions, originally introduced in 1957 by Shin’ichi Kinoshita and Hide- taka Terasaka [3], have since been studied due to their failure to be distinguished by some invariants. In his 2000 paper, Mikhail Khovanov ...